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BioLiP

Structure of PDB 3eqy Chain B

Receptor sequence
>3eqyB (length=84) Species: 9606 (Homo sapiens) [Search protein sequence]
NQVRPKLPLLKILHAAGAQGEMFTVKEVMHYLGQYIMVKQLYDAAAQHMV
YCGGDLLGELLGRQSFSVKDPSPLYDMLRKNLVT
3D structure
PDB3eqy Structural basis for high-affinity peptide inhibition of p53 interactions with MDM2 and MDMX.
ChainB
Resolution1.63 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide B M53 L56 G57 I60 M61 Y66 Q71 H72 V92 Y99 M29 L32 G33 I36 M37 Y42 Q47 H48 V68 Y75
Gene Ontology
Biological Process
GO:0043066 negative regulation of apoptotic process
GO:0051726 regulation of cell cycle
Cellular Component
GO:0005634 nucleus

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Cellular Component
External links
PDB RCSB:3eqy, PDBe:3eqy, PDBj:3eqy
PDBsum3eqy
PubMed19255450
UniProtO15151|MDM4_HUMAN Protein Mdm4 (Gene Name=MDM4)

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