Structure of PDB 3akk Chain B

Receptor sequence
>3akkB (length=288) Species: 85963 (Helicobacter pylori J99) [Search protein sequence]
PTIDFTFCEINPKKGFGGANGNKISLFYNNELYMVKFPPKPTNGCFSEYV
ACHIVNSLGLKVQETLLGTYKNKIVVACKDFTTHQYELVDFLSLKNTMIE
LEKSGKDTNLNDVLYAIDNQHFIEPKVLKCFFWDMFVADTLLGNFDRHNG
NWGFLRASNSKEYQIAPIFDCGSCLYPQADDVVCQKVLSNIDELNARIYN
FPQSILKDDNDKKINYYDFLTQTNNKDCLDALLRIYPRIDMNKIHSIIDN
TPFMSEIHKEFLHTMLDERKSKIIDVAHTRAIELSLQH
3D structure
PDB3akk Helicobacter pylori proinflammatory protein up-regulates NF-kappaB as a cell-translocating Ser/Thr kinase
ChainB
Resolution2.5 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MG B N160 D179 N151 D170
BS02 ADP B G18 N21 K24 M35 K37 Q72 D89 F90 L97 D179 G17 N20 K23 M34 K36 Q63 D80 F81 L88 D170
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0000287 magnesium ion binding
GO:0004674 protein serine/threonine kinase activity
GO:0005524 ATP binding
GO:0044024 histone H2AS1 kinase activity
GO:0046872 metal ion binding
GO:0106310 protein serine kinase activity
Biological Process
GO:0001819 positive regulation of cytokine production
GO:0006338 chromatin remodeling
GO:0016310 phosphorylation
GO:0033138 positive regulation of peptidyl-serine phosphorylation
GO:0051092 positive regulation of NF-kappaB transcription factor activity
GO:1901224 positive regulation of non-canonical NF-kappaB signal transduction
Cellular Component
GO:0005576 extracellular region
GO:0030430 host cell cytoplasm
GO:0042025 host cell nucleus
GO:0044164 host cell cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:3akk, PDBe:3akk, PDBj:3akk
PDBsum3akk
PubMed21098302
UniProtQ9ZKJ5|CTKA_HELPJ Serine/threonine-protein kinase CtkA (Gene Name=ctkA)

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