Structure of PDB 2pul Chain B

Receptor sequence

>2pulB (length=369) Species: 1423 (Bacillus subtilis) [Search protein sequence]

PLYETLNESSAVALAVKLGLTCQEIGDGNLNYVFHIYRALIIKQAVPPLT
IDRARIESSALIRQGEHVPHLVPRVFYSDTEMAVTVMEDLSHLKIARKGL
IEGENYPHLSQHIGEFLGKTLFYSSDYALEPKVKKQLVKQFTNPELCDIT
ERLVFTDPFFDHDTNDFEEELRPFVEKLWNNDSVKIEAAKLKKSFLTSAE
TLIHGDLHTGSIFASEHETKVIDPEFAFYGPIGFDVGQFIANLFLNALSR
DGADREPLYEHVNQVWETFEETFSEAWQKDSLDVYANIDGYLTDTLSHIF
EEAIGFAGCELIRRTIGLAHVADLDTIVPFDKRIGRKRLALETGTAFIEK
RSEFKTITDVIELFKLLVK

3D structure

PDB

2pul Structures of 5-methylthioribose kinase reveal substrate specificity and unusual mode of nucleotide binding

Chain

Resolution

2.0 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

2.7.1.100: S-methyl-5-thioribose kinase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	MG	B	D250 E252	D223 E225
BS02	ACP	B	D40 N44 I59 K61 M114 D116 L117 F240 D250	D27 N31 I41 K43 M87 D89 L90 F213 D223

Gene Ontology

	Molecular Function
GO:0005524	ATP binding
GO:0016301	kinase activity
GO:0046522	S-methyl-5-thioribose kinase activity

	Biological Process
GO:0009086	methionine biosynthetic process
GO:0016310	phosphorylation
GO:0019509	L-methionine salvage from methylthioadenosine

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Molecular Function

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Biological Process

External links

PDB	RCSB:2pul, PDBe:2pul, PDBj:2pul
PDBsum	2pul
PubMed	17522047
UniProt	O31663\|MTNK_BACSU Methylthioribose kinase (Gene Name=mtnK)

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