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BioLiP

Structure of PDB 2ns8 Chain B

Receptor sequence
>2ns8B (length=204) Species: 83333 (Escherichia coli K-12) [Search protein sequence]
LDKSKVINSALELLNEVGIEGLTTRKLAQKLGVEQPTLYWHVKNKRALLD
ALAIEMLDRHHTHFSPLEGESWQDFLRNNAKSFRNALLSHRDGAKVHLGT
RPTEKQYETLENQLAFLTQQGFSLENALYALSAVGHFTLGSVLEDQEHQV
AKEERETPTTDSMPPLLRQAIELFDHQGAEPAFLHGLESLIRGFEVQLTA
LLQI
3D structure
PDB2ns8 How an agonist peptide mimics the antibiotic tetracycline to induce Tet-repressor
ChainB
Resolution2.55 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide B E147 D148 H151 K155 E156 M166 I174 F177 G181 A182 E144 D145 H148 K152 E153 M163 I171 F174 G178 A179
BS02 peptide B H64 F67 F86 R104 P105 Y110 L113 L131 L134 H139 H61 F64 F83 R101 P102 Y107 L110 L128 L131 H136
Gene Ontology
Molecular Function
GO:0000976 transcription cis-regulatory region binding
GO:0003677 DNA binding
GO:0003700 DNA-binding transcription factor activity
GO:0046872 metal ion binding
Biological Process
GO:0006355 regulation of DNA-templated transcription
GO:0045892 negative regulation of DNA-templated transcription
GO:0046677 response to antibiotic

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Molecular Function
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Biological Process
External links
PDB RCSB:2ns8, PDBe:2ns8, PDBj:2ns8
PDBsum2ns8
PubMed17374541
UniProtP04483|TETR2_ECOLX Tetracycline repressor protein class B from transposon Tn10 (Gene Name=tetR)

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