Structure of PDB 2e91 Chain B

Receptor sequence
>2e91B (length=283) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence]
KMEAKIDELINNDPVWSSQNESLISKPYNHILLLNLIVQINRVMNLPKDQ
LAIVSQIVELLHNSSLLIDDIEDNAPLRRGQTTSHLIFGVPSTINTANYM
YFRAMQLVSQLTTKEPLYHNLITIFNEELINLHRGQGLDIYWRDFLPEII
PTQEMYLNMVMNKTGGLFRLTLRLMEALSPSHSLVPFINLLGIIYQIRDD
YLNLKDFQAEDITEGKLSFPIVHALNFTKTKGQTEQHNEILRILLLRTSD
KDIKLKLIQILEFDTNSLAYTKNFINQLVNMIK
3D structure
PDB2e91 Bisphosphonates target multiple sites in both cis- and trans-prenyltransferases
ChainB
Resolution2.14 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.5.1.-
2.5.1.1: dimethylallyltranstransferase.
2.5.1.10: (2E,6E)-farnesyl diphosphate synthase.
2.5.1.29: geranylgeranyl diphosphate synthase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MG B D80 D84 D69 D73
BS02 MG B D80 D84 D69 D73
BS03 ZOL B D80 R89 Q147 K174 D214 K238 D69 R78 Q136 K163 D199 K216 BindingDB: IC50=6.6e+2nM,Ki=260nM
Gene Ontology
Molecular Function
GO:0004161 dimethylallyltranstransferase activity
GO:0004311 farnesyltranstransferase activity
GO:0004337 geranyltranstransferase activity
GO:0004659 prenyltransferase activity
GO:0016740 transferase activity
GO:0046872 metal ion binding
Biological Process
GO:0008299 isoprenoid biosynthetic process
GO:0015031 protein transport
GO:0016114 terpenoid biosynthetic process
GO:0033384 geranyl diphosphate biosynthetic process
GO:0033386 geranylgeranyl diphosphate biosynthetic process
GO:0045337 farnesyl diphosphate biosynthetic process
Cellular Component
GO:0005737 cytoplasm
GO:0005739 mitochondrion

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:2e91, PDBe:2e91, PDBj:2e91
PDBsum2e91
PubMed17535895
UniProtQ12051|GGPPS_YEAST Geranylgeranyl pyrophosphate synthase BTS1 (Gene Name=BTS1)

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