Structure of PDB 1zaf Chain B

Receptor sequence

>1zafB (length=228) Species: 9606 (Homo sapiens) [Search protein sequence]

LSPEQLVLTLLEAEPPHVLISRPSAPFTEASMMMSLTKLADKELVHMISW
AKKIPGFVELSLFDQVRLLESCWMEVLMMGLMWRSIDHPGKLIFAPDLVL
DRDEGKCVEGILEIFDMLLATTSRFRELKLQHKEYLCVKAMILLNSAMDS
SRKLAHLLNAVTDALVWVIAKSGISSQQQSMRLANLLMLLSHVRHASNKG
MEHLLNMKCKNVVPVYDLLLEMLNAHVL

3D structure

PDB

1zaf Estrogen receptor ligands: design and synthesis of new 2-arylindene-1-ones

Chain

Resolution

2.2 Å

3D
structure

[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]

Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	peptide	B	I310 K314 V328 L490 E493 V499	I48 K52 V66 L218 E221 V227
BS02	789	B	E305 M336 L339 F356 I373 H475 L476	E43 M74 L77 F94 I111 H203 L204	MOAD: ic50=20nM BindingDB: IC50=20nM

External links

PDB	RCSB:1zaf, PDBe:1zaf, PDBj:1zaf
PDBsum	1zaf
PubMed	15876535
UniProt	Q92731\|ESR2_HUMAN Estrogen receptor beta (Gene Name=ESR2)

[Back to BioLiP]