BioLiP

Structure of PDB 1u54 Chain B

Receptor sequence

>1u54B (length=261) Species: 9606 (Homo sapiens) [Search protein sequence]

LTCLIGEKDLRLLEKLGDGVVRRGEWDAPSGKTVSVAVKCLEAMDDFIRE
VNAMHSLDHRNLIRLYGVVLTPPMKMVTELAPLGSLLDRLRKHQGHFLLG
TLSRYAVQVAEGMGYLESKRFIHRDLAARNLLLATRDLVKIGDFGLMRAL
PQNDDHYVMQEHRKVPFAWCAPESLKTRTFSHASDTWMFGVTLWEMFTYG
QEPWIGLNGSQILHKIDKEGERLPRPEDCPQDIYNVMVQCWAHKPEDRPT
FVALRDFLLEA

3D structure

PDB

1u54 Crystal Structures of the Phosphorylated and Unphosphorylated Kinase Domains of the Cdc42-associated Tyrosine Kinase ACK1.

Chain

Resolution

2.8 Å

3D
structure

Catalytic site residues are labeled in the structure
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Enzymatic activity

Catalytic site (original residue number in PDB)	D252 A254 R256 N257 D270 V292
Catalytic site (residue number reindexed from 1)	D125 A127 R129 N130 D143 V165
Enzyme Commision number	2.7.10.2: non-specific protein-tyrosine kinase. 2.7.11.1: non-specific serine/threonine protein kinase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	MG	B	N257 D270	N130 D143
BS02	ACP	B	L132 G133 V140 A156 K158 L207 A208 L259 D270	L16 G17 V21 A37 K39 L80 A81 L132 D143

Gene Ontology

	Molecular Function
GO:0004672	protein kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005524	ATP binding

	Biological Process
GO:0006468	protein phosphorylation

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Molecular Function

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Biological Process

PDB	RCSB:1u54, PDBe:1u54, PDBj:1u54
PDBsum	1u54
PubMed	15308621
UniProt	Q07912\|ACK1_HUMAN Activated CDC42 kinase 1 (Gene Name=TNK2)