Structure of PDB 1siv Chain B

Receptor sequence

>1sivB (length=99) Species: 11723 (Simian immunodeficiency virus) [Search protein sequence]

PQFSLWRRPVVTAHIEGQPVEVLLDTGADDSIVTGIELGPHYTPKIVGGI
GGFINTKEYKNVKIEVLGKRIKGTIMTGDTPINIFGRNLLTALGMSLNL

3D structure

PDB

1siv Three-dimensional structure of a simian immunodeficiency virus protease/inhibitor complex. Implications for the design of human immunodeficiency virus type 1 and 2 protease inhibitors.

Chain

Resolution

2.5 Å

3D
structure

Catalytic site residues are labeled in the structure
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Enzymatic activity

Catalytic site (original residue number in PDB)	D25 T26 G27
Catalytic site (residue number reindexed from 1)	D25 T26 G27
Enzyme Commision number	2.7.7.- 2.7.7.49: RNA-directed DNA polymerase. 2.7.7.7: DNA-directed DNA polymerase. 3.1.-.- 3.1.13.2: exoribonuclease H. 3.1.26.13: retroviral ribonuclease H. 3.4.23.16: HIV-1 retropepsin.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	PSI	B	D25 G27 A28 D29 D30 G48 G49	D25 G27 A28 D29 D30 G48 G49	MOAD: Ki=8.4nM PDBbind-CN: -logKd/Ki=8.08,Ki=8.4nM

Gene Ontology

	Molecular Function
GO:0004190	aspartic-type endopeptidase activity

	Biological Process
GO:0006508	proteolysis

View graph for
Molecular Function

View graph for
Biological Process

External links

PDB	RCSB:1siv, PDBe:1siv, PDBj:1siv
PDBsum	1siv
PubMed	8241159
UniProt	P05896\|POL_SIVM1 Gag-Pol polyprotein (Gene Name=gag-pol)

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