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BioLiP

Structure of PDB 1kop Chain B

Receptor sequence
>1kopB (length=223) Species: 485 (Neisseria gonorrhoeae) [Search protein sequence]
HTHWGYTGHDSPESWGNLSEEFRLCSTGKNQSPVNITETVSGKLPAIKVN
YKPSMVDVENNGHTIQVNYPEGGNTLTVNGRTYTLKQFHFHVPSENQIKG
RTFPMEAHFVHLDENKQPLVLAVLYEAGKTNGRLSSIWNVMPMTAGKVKL
NQPFDASTLLPKRLKYYRFAGSLTTPPCTEGVSWLVLKTYDHIDQAQAEK
FTRAVGSENNRPVQPLNARVVIE
3D structure
PDB1kop Crystal structure of carbonic anhydrase from Neisseria gonorrhoeae and its complex with the inhibitor acetazolamide.
ChainB
Resolution1.9 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) H66 H92 H94 E98 H111 T177
Catalytic site (residue number reindexed from 1) H63 H89 H91 E95 H108 T174
Enzyme Commision number 4.2.1.1: carbonic anhydrase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN B H92 H94 H111 H89 H91 H108
Gene Ontology
Molecular Function
GO:0004089 carbonate dehydratase activity
GO:0008270 zinc ion binding
GO:0016829 lyase activity
GO:0046872 metal ion binding
Cellular Component
GO:0042597 periplasmic space

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Molecular Function
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Cellular Component
External links
PDB RCSB:1kop, PDBe:1kop, PDBj:1kop
PDBsum1kop
PubMed9761692
UniProtQ50940|CAH_NEIGO Carbonic anhydrase (Gene Name=cah)

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