BioLiP

Structure of PDB 1cb2 Chain B

Receptor sequence

>1cb2B (length=363) Species: 51453 (Trichoderma reesei) [Search protein sequence]

TATYSGNPFVGVTPWANAYYASEVSSLAIPSLTGAMATAAAAVAKVPSFM
WLDTLDKTPLMEQTLADIRTANKNGGNYAGQFVVFDLPDRDCAALASNGE
YSIADGGVAKYKNYIDTIRQIVVEYSDIRTLLVIEPDSLANLVTNLGTPK
CANAQSAYLECINYAVTQLNLPNVAMYLDAGHAGWLGWPANQDPAAQLFA
NVYKNASSPRALRGLATNVANYNGWNITSPPSYTQGNAVYNEKLYIHAIG
PLLANHGWSNAFFITDQGRSGKQPTGQQQWGDWCNVIGTGFGIRPSANTG
DSLLDSFVWVKPGGECDGTSDSSAPRFDSHCALPDALQPAPQAGAWFQAY
FVQLLTNANPSFL

3D structure

PDB

1cb2 The active site of Trichoderma reesei cellobiohydrolase II: the role of tyrosine 169.

Chain

Resolution

2.0 Å

3D
structure

Catalytic site residues are labeled in the structure
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Enzymatic activity

Catalytic site (original residue number in PDB)	F169 R174 D175 S181 D221 D401
Catalytic site (residue number reindexed from 1)	F85 R90 D91 S97 D137 D317
Enzyme Commision number	3.2.1.91: cellulose 1,4-beta-cellobiosidase (non-reducing end).

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	MAN	B	T97 N161	T13 N77
BS02	MAN	B	Y103 S106	Y19 S22
BS03	MAN	B	S109 A125	S25 A41
BS04	MAN	B	S106 S110	S22 S26
BS05	MAN	B	L111 S115	L27 S31
BS06	MAN	B	G118 T122	G34 T38

Gene Ontology

	Molecular Function
GO:0004553	hydrolase activity, hydrolyzing O-glycosyl compounds

	Biological Process
GO:0005975	carbohydrate metabolic process
GO:0030245	cellulose catabolic process

View graph for
Molecular Function

View graph for
Biological Process

PDB	RCSB:1cb2, PDBe:1cb2, PDBj:1cb2
PDBsum	1cb2
PubMed	8875646
UniProt	P07987\|GUX2_HYPJE Exoglucanase 2 (Gene Name=cbh2)