Structure of PDB 8zwv Chain A

Receptor sequence

>8zwvA (length=260) Species: 9606 (Homo sapiens)

MSHHWGYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTAKYDPSLKPLSVS
YDQATSLRILNNGHAFNVEFDDSQDKAVLKGGPLDGTYRLIQFHFHWGSL
DGQGSEHTVDKKKYAAELHLVHWNTKYGDFGKAVQQPDGLAVLGIFLKVG
SAKPGLQKVVDVLDSIKTKGKSADFTNFDPRGLLPESLDYWTYPGSLTTP
PLLECVTWIVLKEPISVSSEQVLKFRKLNFNGEGEPEELMVDNWRPAQPL
KNRQIKASFK

3D structure

• PDB: 8zwv The Crystal Structure of carbonic anhydrase II from Biortus.
• Chain: A
• Resolution: 1.5 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	V7Z	A	H94 H96 H119 L197 T198	H94 H96 H119 L197 T198
BS02	ZN	A	H94 H96 H119	H94 H96 H119

Gene Ontology

Molecular Function

• GO:0004064 arylesterase activity
• GO:0004089 carbonate dehydratase activity
• GO:0005515 protein binding
• GO:0008270 zinc ion binding
• GO:0016829 lyase activity
• GO:0018820 cyanamide hydratase activity
• GO:0046872 metal ion binding

Biological Process

• GO:0002009 morphogenesis of an epithelium
• GO:0006730 one-carbon metabolic process
• GO:0015670 carbon dioxide transport
• GO:0032230 positive regulation of synaptic transmission, GABAergic
• GO:0032849 positive regulation of cellular pH reduction
• GO:0038166 angiotensin-activated signaling pathway
• GO:0044070 regulation of monoatomic anion transport
• GO:0046903 secretion
• GO:0051453 regulation of intracellular pH
• GO:0070050 neuron cellular homeostasis
• GO:2001150 positive regulation of dipeptide transmembrane transport
• GO:2001225 regulation of chloride transport

Cellular Component

• GO:0005737 cytoplasm
• GO:0005829 cytosol
• GO:0005886 plasma membrane
• GO:0043209 myelin sheath
• GO:0045177 apical part of cell
• GO:0070062 extracellular exosome

External links

• PDB: RCSB:8zwv, PDBe:8zwv, PDBj:8zwv
• PDBsum: 8zwv
• UniProt: P00918|CAH2_HUMAN Carbonic anhydrase 2 (Gene Name=CA2)