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BioLiP

Structure of PDB 8zmf Chain A

Receptor sequence
>8zmfA (length=331) Species: 562,9606 [Search protein sequence]
KFPDGVQNWPALSIVIIIIMTIGGNILVIMAVSMEKKLHNATNYFLMSLA
IADMLVGLLVMPLSLLAILYDYVWPLPRYLCPVWISLDVLFSTASIMHLC
AISLDRYVAIRNPIFNSRTKAIMKIAIVWAISIGVSVPIPVIGLRDEEKV
FVNNTTCVLNDPNFVLIGSFVAFFIPLTIMVITYCLTIYVLRRQAADLED
NWETLNDNLKVIALTKMRAAALDAQKARHGFDILTRNAYIQKYLQAINNE
RKASKVLGIVFFVFLIMWCPFFITNILSVLCEKSCNQKLMEKLLNVFVWI
GYVNSGINPLVYTLFNKIYRRAFSNYLRCNY
3D structure
PDB8zmf Dual 5-HT 2A and 5-HT 2C Receptor Inverse Agonist That Affords In Vivo Antipsychotic Efficacy with Minimal hERG Inhibition for the Treatment of Dementia-Related Psychosis.
ChainA
Resolution3.6 Å
3D
structure
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Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 A1L10 A D134 V135 S138 T139 I142 V185 I189 F214 G218 W324 F327 F328 V354 D88 V89 S92 T93 I96 V135 I139 F164 G168 W268 F271 F272 V298
External links
PDB RCSB:8zmf, PDBe:8zmf, PDBj:8zmf
PDBsum8zmf
PubMed39137033
UniProtP0ABE7|C562_ECOLX Soluble cytochrome b562 (Gene Name=cybC);
P28335|5HT2C_HUMAN 5-hydroxytryptamine receptor 2C (Gene Name=HTR2C)

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