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BioLiP

Structure of PDB 8x43 Chain A

Receptor sequence
>8x43A (length=327) Species: 9606 (Homo sapiens) [Search protein sequence]
RNAFYRKLQNFLYNVLERPRGWAFIYHAYVFLLVFSCLVLSVFSTIKEYE
KSSEGALYILEIVTIVVFGVEYFVRIWAAGCCCRYRGWRGRLKFARKPFC
VIDIMVLIASIAVSALRSLRFLQILRMIRMDRRGGTWKLLGSVVYAHSKE
LVTAWYIGFLCLILASFLVYLAEKGENDHFDTYADALWWGLITLTTIGYG
DKYPQTWNGRLLAATFTLIGVSFFALPAGILGSGFALKVQEQHRQKHFEK
RRNPAAGLIQSAWRFYATNVSIRAVCVMRFLVSKRKFKESLRPYDVMDVI
EQYSAGHLDMLSRIKSLQSRVDQIVGR
3D structure
PDB8x43 A small-molecule activation mechanism that directly opens the KCNQ2 channel.
ChainA
Resolution3.0 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 7Q0 A L299 S303 F304 L218 S222 F223
BS02 7Q0 A W236 F305 P308 W155 F224 P227
Gene Ontology
Molecular Function
GO:0005216 monoatomic ion channel activity
GO:0005249 voltage-gated potassium channel activity
Biological Process
GO:0006811 monoatomic ion transport
GO:0006813 potassium ion transport
GO:0055085 transmembrane transport
Cellular Component
GO:0016020 membrane

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Cellular Component
External links
PDB RCSB:8x43, PDBe:8x43, PDBj:8x43
PDBsum8x43
PubMed38167918
UniProtO43526|KCNQ2_HUMAN Potassium voltage-gated channel subfamily KQT member 2 (Gene Name=KCNQ2)

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