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Structure of PDB 8v1q Chain A

Receptor sequence

>8v1qA (length=1097) Species: 10306 (Human alphaherpesvirus 1 strain KOS)

GPTQRHTYYSECDEFRFIAPRVLDEDAPPEKRAGVHDGHLKRAPKVYCGG
DERDVLRVGSGGFWPRRSRLWGGVDHAPAGFNPTVTVFHVYDILENVEHA
YGMRAAQFHARFMDAITPTGTVITLLGLTPEGHRVAVHVYGTRQYFYMNK
EEVDRHLQCRAPRDLCERMAAALRESPGASFRGISADHFEAEVVERTDVY
YYETRPALFYRVYVRSGRVLSYLCDNFCPAIKKYEGGVDATTRFILDNPG
FVTFGWYRLKPGRNNTLAQPRAPMAFGTSSDVEFNCTADNLAIEGGMSDL
PAYKLMCFDIECKAGGEDELAFPVAGHPEDLVIQISCLLYDLSTTALEHV
LLFSLGSCDLPESHLNELAARGLPTPVVLEFDSEFEMLLAFMTLVKQYGP
EFVTGYNIINFDWPFLLAKLTDIYKVPLDGYGRMNGRGVFRVWDIGQSHF
QKRSKIKVNGMVNIDMYGIITDKIKLSSYKLNAVAEAVLKDKKKDLSYRD
IPAYYATGPAQRGVIGEYCIQDSLLVGQLFFKFLPHLELSAVARLAGINI
TRTIYDGQQIRVFTCLLRLADQKGFILPDTQGRFRGAGRHVGYQGARVLD
PTSGFHVNPVVVFDFASLYPSIIQAHNLCFSTLSLRADAVAHLEAGKDYL
EIEVGGRRLFFVKAHVRESLLSILLRDWLAMRKQIRSRIPQSSPEEAVLL
DKQQAAIKVVCNSVYGFTGVQHGLLPCLHVAATVTTIGREMLLATREYVH
ARWAAFEQLLADFPEAADMRAPGPYSMRIIYGDTDSIFVLCRGLTAAGLT
AMGDKMASHISRALFLPPIKLECEKTFTKLLLIAKKKYIGVIYGGKMLIK
GVDLVRKNNCAFINRTSRALVDLLFYDDTVSGAAAALAERPAEEWLARPL
PEGLQAFGAVLVDAHRRITDPERDIQDFVLTAELSRHPRAYTNKRLAHLT
VYYKLMARRAQVPSIKDRIPYVIVAQTREVEETVARLAALRELDAPRKLL
VSELAEDPAYAIAHGVALNTDYYFSHLLGAACVTFKALFGNNAKITESLL
KRFIPEVWHPPDDVAARLRAAGFGAVGAGATAEETRRMLHRAFDTLA

3D structure

• PDB: 8v1q Viral DNA polymerase structures reveal mechanisms of antiviral drug resistance.
• Chain: A
• Resolution: 2.7 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	dna	A	K534 R692 D886 T887 D888 K939 Y941 K953 G954 R959 K960 E1036 S1038 R1039 Y1044 T1045 N1046 H1051 R1071	K475 R589 D783 T784 D785 K836 Y838 K850 G851 R856 K857 E933 S935 R936 Y941 T942 N943 H948 R968
BS02	dna	A	W502 F509 Q510 K511 K514 G616 Q617 Q618 Q640 F643 R644 V694 G695 Y696 Q697 G698 A699 V701 G819 G822 V823 K938 K939 K940 R1048 L1138 V1139 S1140 H1164 V1171 K1174	W443 F450 Q451 K452 K455 G557 Q558 Q559 Q581 F584 R585 V591 G592 Y593 Q594 G595 A596 V598 G716 G719 V720 K835 K836 K837 R945 L1000 V1001 S1002 H1026 V1033 K1036
BS03	MG	A	D368 G464 Y465	D309 G405 Y406

External links

• PDB: RCSB:8v1q, PDBe:8v1q, PDBj:8v1q
• PDBsum: 8v1q
• PubMed: 39197451
• UniProt: H9E937

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