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BioLiP

Structure of PDB 8jt8 Chain A

Receptor sequence
>8jt8A (length=355) Species: 562,9606 [Search protein sequence]
KNWSALLTAVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLL
GFLVMPVSMLTILYGYRWPLPSKLCAVWIYLDVLFSTAKIWHLCAISLDR
YVAIQNPSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVFKEGSCLLA
DDNFVLIGSFVSFFIPLTIMVITYFLTIKSLQKEAADLEDNWETLNDNLK
VIEKADNAAQVKDALTKMRAAALDADILVGQIDDALKLANEGKVKEAQAA
AEQLKTTINAYIQKYGQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMA
VICKESCNEDVIGALLNVFVWIGYLNSAVNPLVYTLFNKTYRSAFSRYIQ
CQYKE
3D structure
PDB8jt8 Flexible Scaffold-based Cheminformatics Approach for Polypharmacological Drug Design
ChainA
Resolution2.7 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MG A E1008 D1012 E193 D197
BS02 EZX A D155 V156 S159 T160 I163 L228 L229 F243 F332 W336 F339 F340 L362 N363 V366 D82 V83 S86 T87 I90 L148 L149 F163 F286 W290 F293 F294 L316 N317 V320
BS03 CLR A T342 C353 I358 L361 T296 C307 I312 L315
BS04 CLR A A90 I93 M97 Y394 Y399 A17 I20 M24 Y348 Y353
Gene Ontology
Molecular Function
GO:0004930 G protein-coupled receptor activity
GO:0004993 G protein-coupled serotonin receptor activity
GO:0005506 iron ion binding
GO:0009055 electron transfer activity
GO:0020037 heme binding
Biological Process
GO:0007186 G protein-coupled receptor signaling pathway
GO:0022900 electron transport chain
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane

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Cellular Component
External links
PDB RCSB:8jt8, PDBe:8jt8, PDBj:8jt8
PDBsum8jt8
PubMed38552625
UniProtP0ABE7|C562_ECOLX Soluble cytochrome b562 (Gene Name=cybC);
P28223|5HT2A_HUMAN 5-hydroxytryptamine receptor 2A (Gene Name=HTR2A)

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