Structure of PDB 8cav Chain A

Receptor sequence
>8cavA (length=860) Species: 2020 (Thermomonospora curvata) [Search protein sequence]
ATPTEQELRAELTGPVTGAGRQIHARGVWLAVDDPAFHLPRQGWKIHLSA
RPATLQETIRRMLPAVLAVPCHFKVVRSGRHLQDLNSANNHPGSIGKAVT
IYPSPEDVAPLARRLAEDLAGMAGPRICSDRRVRPDAPVYYRYGPFHPCY
DINDDGDLELVVTDPQGNTHPGAADDSFWQPHWSPDPLTGATPHPAPSDG
PAAPVLLGGRYRVVRGLTRNGKGCVYRAIDTTDNRPVIIKEARAHVNEDT
LGRDSRLRLRNERYVLHLLRDLDDVPKVIDHFRHEDREYLAITDLGALAL
GQDVAENGLYVADPAPPGRSLRALATALLELLDHVHRRGVLVRDLTPTNV
VLDDATGRPRLVDFEISHAEDPQLYGWTPGYSPPEQERDEPATVEADYYS
LGATLFYAATGLPPTWMTGDPGNHDPRRAAEVLAGRGGMSGTILGLLDPD
PARRRAAADDIRAGRFTDAPPPPPPSARQRARRLAAAIAHSLTELSRHAA
DLMSGKDFTGGLVGSPINLYRGAAGMGMELLRHDEPSRALARGLAYWTGG
FRALRNGRPGLYTGDTGIAVFIAEAGATLGDETLLKIAEPLARPVLSRIT
ATDQHTGLAGIGTGQLLLWRLTKDAGRLELADACARRLLARDLTAELQEN
PPDYADCGAVSRTLGFAHGLAGIVHFLRDHHAATGETATEAALHKGCDTL
LEHLPPLLEAARAVSAKPMHASFCQGLAGIGAALARTGRDLGADDHLQAA
REAAAACLELAPRMYALTQCCGLAGIGELFLDLCQITGDRTYAQWADRIA
DLILARAGGSPEAPVFPDTSLHGSSGGWSIGTSGVVSFLRRLGDPAAPRL
WLDPPAGTAR
3D structure
PDB8cav Discovery of the Lanthipeptide Curvocidin and Structural Insights into its Trifunctional Synthetase CuvL.
ChainA
Resolution2.87 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A L211 R220 G221 H286 F287 R288 H289 E293 L206 R215 G216 H281 F282 R283 H284 E288
BS02 ANP A K227 V230 K245 T298 L300 T353 V356 V367 D368 K222 V225 K240 T293 L295 T348 V351 V362 D363
BS03 MG A N354 D368 N349 D363
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0005524 ATP binding
GO:0046872 metal ion binding
Biological Process
GO:0005975 carbohydrate metabolic process
GO:0006468 protein phosphorylation
GO:0016310 phosphorylation
GO:0018105 peptidyl-serine phosphorylation
GO:0031179 peptide modification

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Molecular Function
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Biological Process
External links
PDB RCSB:8cav, PDBe:8cav, PDBj:8cav
PDBsum8cav
PubMed37014271
UniProtD1A2F7

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