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BioLiP

Structure of PDB 8alx Chain A

Receptor sequence
>8alxA (length=115) Species: 9606 (Homo sapiens) [Search protein sequence]
TVTVPKDLYVVEYGSNMTIECKFPVEKQLDLAALIVYWEMEDKNIIQFVH
GEEDLKVQHSSYRQRARLLKDQLSLGNAALQITDVKLQDAGVYRCMISYG
GADYKRITVKVNAPY
3D structure
PDB8alx Structural and biological characterization of pAC65, a macrocyclic peptide that blocks PD-L1 with equivalent potency to the FDA-approved antibodies.
ChainA
Resolution1.1 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A I54 Y56 N63 Q66 V68 D73 V76 R113 C114 M115 Y123 R125 I35 Y37 N44 Q47 V49 D54 V57 R94 C95 M96 Y104 R106
External links
PDB RCSB:8alx, PDBe:8alx, PDBj:8alx
PDBsum8alx
PubMed37679783
UniProtQ9NZQ7|PD1L1_HUMAN Programmed cell death 1 ligand 1 (Gene Name=CD274)

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