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BioLiP

Structure of PDB 7ztl Chain A

Receptor sequence
>7ztlA (length=264) Species: 9606 (Homo sapiens) [Search protein sequence]
RQWALEDFEIGRPLGKGKFGNVYLAREKQSKFILALKVLFKAQLEKAGVE
HQLRREVEIQSHLRHPNILRLYGYFHDATRVYLILEYAPLGTVYRELQKL
SKFDEQRTATYITELANALSYCHSKRVIHRDIKPENLLLGSAGELKIADF
GWSVHAPSSRRTTLAGTLDYLPPEMIEGRMHDEKVDLWSLGVLCYEFLVG
KPPFEANTYQETYCRISRVEFTFPDFVTEGARDLISRLLKHNPSQRPMLR
EVLEHPWITANSSK
3D structure
PDB7ztl Crystal structure of a covalently linked Aurora-A-MYCN complex
ChainA
Resolution1.9 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A K143 A172 L289 G291 L293 L296 T333 Y334 Q335 Y338 K18 A47 L164 G166 L168 L171 T208 Y209 Q210 Y213
BS02 ADP A G142 V147 A160 K162 A213 T217 E260 L263 D274 G17 V22 A35 K37 A88 T92 E135 L138 D149
BS03 MG A N261 D274 N136 D149
BS04 JWG A Q335 C339 R343 Q210 C214 R218
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:7ztl, PDBe:7ztl, PDBj:7ztl
PDBsum7ztl
PubMed36601802
UniProtO14965|AURKA_HUMAN Aurora kinase A (Gene Name=AURKA)

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