Structure of PDB 7yuj Chain A

Receptor sequence

>7yujA (length=149) Species: 9606 (Homo sapiens) [Search protein sequence]

PGSSAFSYHCKTPDCKGWCFFEDDVNEFTCPVCFHVNCLLCKAIHEQMNC
KEYQEDLALRAQNDVAARQTTEMLKVMLQQGEAMRCPQCQIVVQKKDGCD
WIRCTVCHTEICWVTKGPRWGPGGPGDTSGGCRCRVNGIPCHPSCQNCH

3D structure

PDB

7yuj Mechanistic insights into the enzymatic activity of E3 ligase HOIL-1L and its regulation by the linear ubiquitin chain-binding

Chain

Resolution

1.865 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

2.3.2.31: RBR-type E3 ubiquitin transferase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	ZN	A	C473 C493 C502 C509	C112 C132 C141 C148
BS02	ZN	A	C495 C502 C506 C509	C134 C141 C145 C148
BS03	ZN	A	C447 C450 C465 C468	C86 C89 C104 C107
BS04	ZN	A	C371 C376 C391 C394	C10 C15 C30 C33
BS05	ZN	A	C399 C402 H406 C411	C38 C41 H45 C50

Gene Ontology

	Molecular Function
GO:0008270	zinc ion binding

View graph for
Molecular Function

External links

PDB	RCSB:7yuj, PDBe:7yuj, PDBj:7yuj
PDBsum	7yuj
PubMed	37831767
UniProt	Q9BYM8\|HOIL1_HUMAN RanBP-type and C3HC4-type zinc finger-containing protein 1 (Gene Name=RBCK1)

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