Structure of PDB 7yag Chain A

Receptor sequence
>7yagA (length=876) Species: 9606 (Homo sapiens) [Search protein sequence]
VLTSKKASELPVSEVASILQADLQNGLNKCEVSHRRAFHGWNEFDISPLW
KKYISQFKNPLIMLLLASAVISVLMHQFDDAVSITVAILIVVTVAFVQEY
RSEKSLEELSKLVPPECHCVREGKLEHTLARDLVPGDTVCLSVGDRVPAD
LRLFEAVDLSIDESSLTGETTPCSKVTAPQPAASRSNIAFMGTLVRCGKA
KGVVIGTGENSEFGEVFKMMQAEEAPKTPLQKSMDLLGKQLSFYSFGIIG
IIMLVGWLLGKDILEMFTISVSLAVAAIPEGLPIVVTVTLALGVMRMVKK
RAIVKKLPIVETLGCCNVICSDKTGTLTKNEMTVTHIFTSDGLHAEVTGV
GYNQFGEVIVDGDVVHGFYNPAVSRIVEAGCVCNDAVIRNNTLMGKPTEG
ALIALAMKMGLDGLQQDYIRKAEYPFSSEQKWMAVKCVHRTQQDRPEICF
MKGAYEQVIKYCTTYQSKGQTLTLTQQQRDVYQQEKARMGSAGLRVLALA
SGPELGQLTFLGLVGIIDPPRTGVKEAVTTLIASGVSIKMITGDSQETAV
AIASRLGLYSKTSQSVSGEEIDAMDVQQLSQIVPKVAVFYRASPRHKMKI
IKSLQKNGSVVAMTGDGVNDAVALKAADIGVAMGQTGTDVCKEAADMILV
DDDFQTIMSAIEEGKGIYNNIKNFVRFQLSTSIAALTLISLATLMNFPNP
LNAMQILWINIIMDGPPAQSLGVEPVDKDVIRKPPRNWKDSILTKNLILK
ILVSSIIIVCGTLFVFWRELRDNVITPRDTTMTFTCFVFFDMFNALSSRS
QTKSVFEIGLCSNRMFCYAVLGSIMGQLLVIYFPPLQKVFQTESLSILDL
LFLLGLTSSVCIVAEIIKKVERSREK
3D structure
PDB7yag Cryo-EM structures of human SPCA1a reveal the mechanism of Ca 2+ /Mn 2+ transport into the Golgi apparatus.
ChainA
Resolution3.1 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 7.2.2.10: P-type Ca(2+) transporter.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ACP A T352 E427 F454 S456 K459 K480 R523 L525 T570 G571 R619 T324 E399 F426 S428 K431 K452 R495 L497 T542 G543 R591
BS02 CA A V303 A304 I306 E308 N738 D742 V275 A276 I278 E280 N710 D714
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0005215 transporter activity
GO:0005388 P-type calcium transporter activity
GO:0005524 ATP binding
GO:0016887 ATP hydrolysis activity
GO:0046872 metal ion binding
GO:0140613 P-type manganese transporter activity
Biological Process
GO:0006816 calcium ion transport
GO:0006828 manganese ion transport
GO:0006874 intracellular calcium ion homeostasis
GO:0008544 epidermis development
GO:0016339 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules
GO:0030036 actin cytoskeleton organization
GO:0032468 Golgi calcium ion homeostasis
GO:0032472 Golgi calcium ion transport
GO:0042998 positive regulation of Golgi to plasma membrane protein transport
GO:0043123 positive regulation of canonical NF-kappaB signal transduction
GO:0070588 calcium ion transmembrane transport
GO:0071421 manganese ion transmembrane transport
GO:0098629 trans-Golgi network membrane organization
Cellular Component
GO:0000139 Golgi membrane
GO:0005783 endoplasmic reticulum
GO:0005794 Golgi apparatus
GO:0005802 trans-Golgi network
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0032580 Golgi cisterna membrane
GO:0033106 cis-Golgi network membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7yag, PDBe:7yag, PDBj:7yag
PDBsum7yag
PubMed36867705
UniProtP98194|AT2C1_HUMAN Calcium-transporting ATPase type 2C member 1 (Gene Name=ATP2C1)

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