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BioLiP

Structure of PDB 7wiz Chain A

Receptor sequence
>7wizA (length=556) Species: 7227 (Drosophila melanogaster) [Search protein sequence]
MKYILVTGGVISGVGKGVIASSFGTLLKSCGLDVTSIKIDPYINIDAGTF
SPYEHGEVYVLDDGAEVDLDLGNYERFLDVTLHRDNNITTGKIYKLVIEK
ERTGEYLGKTVQVVPHITDAIQEWVERVAQTPVQGSSKPQVCIVELGGTI
GDIEGMPFVEAFRQFQFRVKRENFCLAHVSLVPLPKATGEPKTKPTQSSV
RELRGCGLSPDLIVCRSEKPIGLEVKEKISNFCHVGPDQVICIHDLNSIY
HVPLLMEQNGVIEYLNERLQLNIDMSKRTKCLQQWRDLARRTETVRREVC
IAVVGKYTKFTDSYASVVKALQHAALAVNRKLELVFIESCLLEEETLHSE
PSKYHKEWQKLCDSHGILVPGGFGSRGMEGKIRACQWARENQKPLLGICL
GLQAAVIEFARNKLGLKDANTTEIDPNTANALVIDMPEHHTGQLGGTMRL
GKRITVFSDGPSVIRQLYGNPKSVQERHRHRYEVNPKYVHLLEEQGMRFV
GTDVDKTRMEIIELSGHPYFVATQYHPEYLSRPLKPSPPFLGLILASVDR
LNQYIQ
3D structure
PDB7wiz Structural basis for ligand binding modes of CTP synthase.
ChainA
Resolution3.2 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 6.3.4.2: CTP synthase (glutamine hydrolyzing).
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GLN A G371 G372 F373 C399 L400 Q403 H480 Y482 G371 G372 F373 C399 L400 Q403 H480 Y482
BS02 ACP A G13 G15 V18 K38 D70 E145 L246 G13 G15 V18 K38 D70 E145 L246
BS03 UTP A K192 T193 K194 K228 K192 T193 K194 K228
BS04 UTP A S12 D40 P41 S12 D40 P41
Gene Ontology
Molecular Function
GO:0003883 CTP synthase activity
Biological Process
GO:0006221 pyrimidine nucleotide biosynthetic process
GO:0006241 CTP biosynthetic process

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Molecular Function
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Biological Process
External links
PDB RCSB:7wiz, PDBe:7wiz, PDBj:7wiz
PDBsum7wiz
PubMed34301892
UniProtQ9VUL1|PYRG_DROME CTP synthase (Gene Name=Ctps)

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