BioLiP

Structure of PDB 7wc6 Chain A

Receptor sequence

>7wc6A (length=355) Species: 562,9606 [Search protein sequence]

KNWSALLTAVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLL
GFLVMPVSMLTILYGYRWPLPSKLCAVWIYLDVLFSTAKIWHLCAISLDR
YVAIQNPSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVFKEGSCLLA
DDNFVLIGSFVSFFIPLTIMVITYFLTIKSLQKEAADLEDNWETLNDNLK
VIEKADNAAQVKDALTKMRAAALDADILVGQIDDALKLANEGKVKEAQAA
AEQLKTTINAYIQKYGQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMA
VICKESCNEDVIGALLNVFVWIGYLNSAVNPLVYTLFNKTYRSAFSRYIQ
CQYKE

3D structure

PDB

7wc6 Structure-based discovery of nonhallucinogenic psychedelic analogs.

Chain

Resolution

2.6 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	MG	A	E1008 D1012	E193 D197
BS02	CLR	A	I341 I358 L361	I295 I312 L315
BS03	7LD	A	W151 I152 D155 V156 S159 V235 G238 W336 F339 F340 N343 V366 Y370	W78 I79 D82 V83 S86 V155 G158 W290 F293 F294 N297 V320 Y324

Gene Ontology

	Molecular Function
GO:0004930	G protein-coupled receptor activity
GO:0004993	G protein-coupled serotonin receptor activity
GO:0005506	iron ion binding
GO:0009055	electron transfer activity
GO:0020037	heme binding

	Biological Process
GO:0007186	G protein-coupled receptor signaling pathway
GO:0022900	electron transport chain

	Cellular Component
GO:0005886	plasma membrane
GO:0016020	membrane

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Molecular Function

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Biological Process

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Cellular Component

PDB	RCSB:7wc6, PDBe:7wc6, PDBj:7wc6
PDBsum	7wc6
PubMed	35084960
UniProt	P0ABE7\|C562_ECOLX Soluble cytochrome b562 (Gene Name=cybC); P28223\|5HT2A_HUMAN 5-hydroxytryptamine receptor 2A (Gene Name=HTR2A)