BioLiP

Structure of PDB 7voe Chain A

Receptor sequence

>7voeA (length=356) Species: 562,9606 [Search protein sequence]

KNWSALLTAVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLL
GFLVMPVSMLTILYGYRWPLPSKLCAVWIYLDVLFSTAKIWHLCAISLDR
YVAIQNPSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVFKEGSCLLA
DDNFVLIGSFVSFFIPLTIMVITYFLTIKSLQKEAADLEDNWETLNDNLK
VIEKADNAAQVKDALTKMRAAALDAGDILVGQIDDALKLANEGKVKEAQA
AAEQLKTTINAYIQKYGQSISNEQKACKVLGIVFFLFVVMWCPFFITNIM
AVICKESCNEDVIGALLNVFVWIGYLNSAVNPLVYTLFNKTYRSAFSRYI
QCQYKE

3D structure

PDB

7voe Structure-based design of a novel third-generation antipsychotic drug lead with potential antidepressant properties.

Chain

Resolution

2.9 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	CLR	A	M97 Y394 Y399	M24 Y349 Y354
BS02	CLR	A	T342 C353 N354 V357 I358 L361	T297 C308 N309 V312 I313 L316
BS03	9SC	A	W151 D155 L228 F243 F332 W336 F339 F340 V366	W78 D82 L148 F163 F287 W291 F294 F295 V321
BS04	MG	A	E1008 D1012	E193 D197

Gene Ontology

	Molecular Function
GO:0004930	G protein-coupled receptor activity
GO:0004993	G protein-coupled serotonin receptor activity
GO:0005506	iron ion binding
GO:0009055	electron transfer activity
GO:0020037	heme binding

	Biological Process
GO:0007186	G protein-coupled receptor signaling pathway
GO:0022900	electron transport chain

	Cellular Component
GO:0005886	plasma membrane
GO:0016020	membrane

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Molecular Function

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Biological Process

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Cellular Component

PDB	RCSB:7voe, PDBe:7voe, PDBj:7voe
PDBsum	7voe
PubMed	34887590
UniProt	P0ABE7\|C562_ECOLX Soluble cytochrome b562 (Gene Name=cybC); P28223\|5HT2A_HUMAN 5-hydroxytryptamine receptor 2A (Gene Name=HTR2A)