Structure of PDB 7voe Chain A

Receptor sequence
>7voeA (length=356) Species: 562,9606 [Search protein sequence]
KNWSALLTAVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLL
GFLVMPVSMLTILYGYRWPLPSKLCAVWIYLDVLFSTAKIWHLCAISLDR
YVAIQNPSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVFKEGSCLLA
DDNFVLIGSFVSFFIPLTIMVITYFLTIKSLQKEAADLEDNWETLNDNLK
VIEKADNAAQVKDALTKMRAAALDAGDILVGQIDDALKLANEGKVKEAQA
AAEQLKTTINAYIQKYGQSISNEQKACKVLGIVFFLFVVMWCPFFITNIM
AVICKESCNEDVIGALLNVFVWIGYLNSAVNPLVYTLFNKTYRSAFSRYI
QCQYKE
3D structure
PDB7voe Structure-based design of a novel third-generation antipsychotic drug lead with potential antidepressant properties.
ChainA
Resolution2.9 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CLR A M97 Y394 Y399 M24 Y349 Y354
BS02 CLR A T342 C353 N354 V357 I358 L361 T297 C308 N309 V312 I313 L316
BS03 9SC A W151 D155 L228 F243 F332 W336 F339 F340 V366 W78 D82 L148 F163 F287 W291 F294 F295 V321
BS04 MG A E1008 D1012 E193 D197
Gene Ontology
Molecular Function
GO:0004930 G protein-coupled receptor activity
GO:0004993 G protein-coupled serotonin receptor activity
GO:0005506 iron ion binding
GO:0009055 electron transfer activity
GO:0020037 heme binding
Biological Process
GO:0007186 G protein-coupled receptor signaling pathway
GO:0022900 electron transport chain
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane

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Cellular Component
External links
PDB RCSB:7voe, PDBe:7voe, PDBj:7voe
PDBsum7voe
PubMed34887590
UniProtP0ABE7|C562_ECOLX Soluble cytochrome b562 (Gene Name=cybC);
P28223|5HT2A_HUMAN 5-hydroxytryptamine receptor 2A (Gene Name=HTR2A)

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