BioLiP

Structure of PDB 7vod Chain A

Receptor sequence

>7vodA (length=355) Species: 562,9606 [Search protein sequence]

KNWSALLTAVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLL
GFLVMPVSMLTILYGYRWPLPSKLCAVWIYLDVLFSTAKIWHLCAISLDR
YVAIQNPSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVFKEGSCLLA
DDNFVLIGSFVSFFIPLTIMVITYFLTIKSLQKEAADLEDNWETLNDNLK
VIEKADNAAQVKDALTKMRAAALDADILVGQIDDALKLANEGKVKEAQAA
AEQLKTTINAYIQKYGQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMA
VICKESCNEDVIGALLNVFVWIGYLNSAVNPLVYTLFNKTYRSAFSRYIQ
CQYKE

3D structure

PDB

7vod Structure-based design of a novel third-generation antipsychotic drug lead with potential antidepressant properties.

Chain

Resolution

3.3 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	MG	A	E1008 D1012	E193 D197
BS02	CLR	A	T342 C353 N354 V357 I358 L361	T296 C307 N308 V311 I312 L315
BS03	CLR	A	A90 I93 M97 Y394 Y399	A17 I20 M24 Y348 Y353
BS04	7RU	A	W151 D155 S159 L228 F243 W336 F339 F340	W78 D82 S86 L148 F163 W290 F293 F294

Gene Ontology

	Molecular Function
GO:0004930	G protein-coupled receptor activity
GO:0004993	G protein-coupled serotonin receptor activity
GO:0005506	iron ion binding
GO:0009055	electron transfer activity
GO:0020037	heme binding

	Biological Process
GO:0007186	G protein-coupled receptor signaling pathway
GO:0022900	electron transport chain

	Cellular Component
GO:0005886	plasma membrane
GO:0016020	membrane

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Molecular Function

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Biological Process

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Cellular Component

PDB	RCSB:7vod, PDBe:7vod, PDBj:7vod
PDBsum	7vod
PubMed	34887590
UniProt	P0ABE7\|C562_ECOLX Soluble cytochrome b562 (Gene Name=cybC); P28223\|5HT2A_HUMAN 5-hydroxytryptamine receptor 2A (Gene Name=HTR2A)