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BioLiP

Structure of PDB 7v3s Chain A

Receptor sequence
>7v3sA (length=284) Species: 9606 (Homo sapiens) [Search protein sequence]
IDLSALNPELVQAVQHVVIGPSSLIVHFNEVIGRGHFGCVYHGTLLDNDG
KKIHCAVKSLNRITDIGEVSQFLTEGIIMKDFSHPNVLSLLGICLRSEGS
PLVVLPYMKHGDLRNFIRNETHNPTVKDLIGFGLQVAKGMKYLASKKFVH
RDLAARNCMLDEKFTVKVADFGLARDMEYYAKLPVKWMALESLQTQKFTT
KSDVWSFGVLLWELMTRGAPPYPDVNTFDITVYLLQGRRLLQPEYCPDPL
YEVMLKCWHPKAEMRPSFSELVSRISAIFSTFIG
3D structure
PDB7v3s Discovery of 10H-Benzo[b]pyrido[2,3-e][1,4]oxazine AXL Inhibitors via Structure-Based Drug Design Targeting c-Met Kinase
ChainA
Resolution1.9 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.10.1: receptor protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 5I9 A I1084 V1092 A1108 K1110 E1127 M1131 F1134 Y1159 M1160 G1163 F1200 M1211 V1220 A1221 D1222 F1223 I32 V40 A56 K58 E75 M79 F82 Y107 M108 G111 F148 M159 V168 A169 D170 F171
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:7v3s, PDBe:7v3s, PDBj:7v3s
PDBsum7v3s
PubMed
UniProtP08581|MET_HUMAN Hepatocyte growth factor receptor (Gene Name=MET)

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