BioLiP

Structure of PDB 7ueu Chain A

Receptor sequence

>7ueuA (length=352) Species: 9606 (Homo sapiens) [Search protein sequence]

SPWFGMDIGGTLVKLSYFEPIDITAEEEQEEVESLKSIRKYLTSNVAYGS
TGIRDVHLELKDLTLFGRRGNLHFIRFPTQDLPTFIQMGRDTVLCATGGG
AYKFEKDFRTIGNLHLHKLDELDCLVKGLLYIDSVSFNGQAECYYFANAS
EPERCQKMPFNLDDPYPLLVVNIGSGVSILAVHSKDNYKRVTGTSLGGGT
FLGLCSLLTGCESFEEALEMASKGDSTQADKLVRDIYGGDYERFGLPGWA
VASSFGNMIYKEKRESVSKEDLARATLVTITNNIGSVARMCAVNEKINRV
VFVGNFLRVNTLSMKLLAYALDYWSKGQLKALFLEHEGYFGAVGALLGLP
NF

3D structure

PDB

7ueu Discovery of hPANK Activators with Improved Pharmacological Properties

Chain

Resolution

2.0 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

2.7.1.33: pantothenate kinase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	YX5	A	E138 V194 R207 G210 T211	E121 V177 R190 G193 T194
BS02	AN2	A	G19 G20 T21 L22 K24 G191 S192 G215 G216 F231 N322 F323 R325	G9 G10 T11 L12 K14 G174 S175 G198 G199 F214 N305 F306 R308

Gene Ontology

	Molecular Function
GO:0004594	pantothenate kinase activity
GO:0005524	ATP binding
GO:0016301	kinase activity
GO:0019842	vitamin binding
GO:0042803	protein homodimerization activity
GO:1905502	acetyl-CoA binding

	Biological Process
GO:0005975	carbohydrate metabolic process
GO:0015937	coenzyme A biosynthetic process
GO:0016310	phosphorylation

	Cellular Component
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005829	cytosol

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Molecular Function

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Biological Process

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Cellular Component

PDB	RCSB:7ueu, PDBe:7ueu, PDBj:7ueu
PDBsum	7ueu
PubMed
UniProt	Q9H999\|PANK3_HUMAN Pantothenate kinase 3 (Gene Name=PANK3)