Structure of PDB 7ran Chain A

Receptor sequence
>7ranA (length=269) Species: 9606 (Homo sapiens) [Search protein sequence]
LLTAVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVM
PVSMLTILYGYRWPLPSKLCAVWIYLDVLFSTASIMHLCAISLDRYVAIQ
NPIHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVFKEGSCL
LADDNFVLIGSFVSFFIPLTIMVITYFLTIKSLQKEATQSISNEQKACKV
LGIVFFLFVVMWCPFFITNIMAVICNEDVIGALLNVFVWIGYLSSAVNPL
VYTLFNKTYRSAFSRYIQC
3D structure
PDB7ran Bespoke library docking for 5-HT 2A receptor agonists with antidepressant activity.
ChainA
Resolution3.45 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 3IQ A D155 F339 F340 D77 F215 F216
Gene Ontology
Molecular Function
GO:0004930 G protein-coupled receptor activity
GO:0004993 G protein-coupled serotonin receptor activity
Biological Process
GO:0007186 G protein-coupled receptor signaling pathway
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane

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Molecular Function
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Cellular Component
External links
PDB RCSB:7ran, PDBe:7ran, PDBj:7ran
PDBsum7ran
PubMed36171289
UniProtP28223|5HT2A_HUMAN 5-hydroxytryptamine receptor 2A (Gene Name=HTR2A)

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