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BioLiP

Structure of PDB 7off Chain A

Receptor sequence
>7offA (length=291) Species: 10090 (Mus musculus) [Search protein sequence]
KVGRLIYTAGGYFRQSLSYLEAYNPSNGSWLRLADLQVPRSGLAGCVVGG
LLYAVGGRNNSPDGNTDSSALDCYNPMTNQWSPCASMSVPRNRIGVGVID
GHIYAVGGSHGCIHHSSVERYEPERDEWHLVAPMLTRRIGVGVAVLNRLL
YAVGGFDGTNRLNSAECYYPERNEWRMITPMNTIRSGAGVCVLHNCIYAA
GGYDGQDQLNSVERYDVETETWTFVAPMRHHRSALGITVHQGKIYVLGGY
DGHTFLDSVECYDPDSDTWSEVTRMTSGRSGVGVAVTMEPC
3D structure
PDB7off Development of Noncovalent Small-Molecule Keap1-Nrf2 Inhibitors by Fragment-Based Drug Discovery.
ChainA
Resolution1.37 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 VCB A R415 R483 S508 G509 Y525 Q530 S555 Y572 F577 R93 R161 S186 G187 Y203 Q208 S233 Y250 F255
External links
PDB RCSB:7off, PDBe:7off, PDBj:7off
PDBsum7off
PubMed36263945
UniProtQ9Z2X8|KEAP1_MOUSE Kelch-like ECH-associated protein 1 (Gene Name=Keap1)

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