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BioLiP

Structure of PDB 7mew Chain A

Receptor sequence
>7mewA (length=572) Species: 562 (Escherichia coli) [Search protein sequence]
STWQTFRRLWPTIAPFKAGLIVAGVALILNAASDTFMLSLLKPLLDDGFG
KTDRSVLVWMPLVVIGLMILRGITSYVSSYCISWVSGKVVMTMRRRLFGH
MMGMPVSFFDKQSTGTLLSRITYDSEQVASSSSGALITVVREGASIIGLF
IMMFYYSWQLSIILIVLAPIVSIAIRVVSKRFRNISKNMQNTMGQVTTSA
EQMLKGHKEVLIFGGQEVETKRFDKVSNRMRLQGMKMVSASSISDPIIQL
IASLALAFVLYAASFPSVMDSLTAGTITVVFSSMIALMRPLKSLTNVNAQ
FQRGMAACQTLFTILDSEQEKDEGKRVIERATGDVEFRNVTFTYPGRDVP
ALRNINLKIPAGKTVALVGRSGSGKSTIASLITRFYDIDEGEILMDGHDL
REYTLASLRNQVALVSQNVHLFNDTVANNIAYARTEQYSREQIEEAARMA
YAMDFINKMDNGLDTVIGENGVLLSGGQRQRIAIARALLRDSPILILDEA
TSALDTESERAIQAALDELQKNRTSLVIAHRLSTIEKADEIVVVEDGVIV
ERGTHNDLLEHRGVYAQLHKMQ
3D structure
PDB7mew Distinct allosteric mechanisms of first-generation MsbA inhibitors.
ChainA
Resolution3.9 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 7.5.2.6: ABC-type lipid A-core oligosaccharide transporter.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 Z5Y A F157 L171 V178 I255 A259 L263 M295 K299 F150 L164 V171 I248 A252 L256 M288 K292
Gene Ontology
Molecular Function
GO:0005524 ATP binding
GO:0016887 ATP hydrolysis activity
GO:0034040 ATPase-coupled lipid transmembrane transporter activity
GO:0140359 ABC-type transporter activity
Biological Process
GO:0006869 lipid transport
GO:0055085 transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane

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External links

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