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BioLiP

Structure of PDB 7d3d Chain A

Receptor sequence
>7d3dA (length=139) Species: 9606 (Homo sapiens) [Search protein sequence]
KVVKFSYMWTINNFSFCREEMGEVIKSSTFSSGANDKLKWCLRVNPKGLD
EESKDYLSLYLLLVSCPKSEVRAKFKFSILNAKGEETKAMESQRAYRFVQ
GKDWGFKKFIRRDFLLDEANGLLPDDKLTLFCEVSVVQD
3D structure
PDB7d3d A peptide binder of E3 ligase adaptor SPOP disrupts oncogenic SPOP-protein interactions in kidney cancer cells.
ChainA
Resolution1.45 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A Y87 E113 T114 K115 A116 M117 E118 S119 Q120 Y123 K129 D130 W131 G132 F133 K134 Y60 E86 T87 K88 A89 M90 E91 S92 Q93 Y96 K102 D103 W104 G105 F106 K107
BS02 peptide A F32 S33 M35 S59 G60 A61 K110 G111 F158 F5 S6 M8 S32 G33 A34 K83 G84 F131
External links
PDB RCSB:7d3d, PDBe:7d3d, PDBj:7d3d
PDBsum7d3d
PubMed
UniProtO43791|SPOP_HUMAN Speckle-type POZ protein (Gene Name=SPOP)

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