BioLiP

Structure of PDB 6xmk Chain A

Receptor sequence

>6xmkA (length=298) Species: 2697049 (Severe acute respiratory syndrome coronavirus 2) [Search protein sequence]

RKMAFPSGKVEGCMVQVTCGTTTLNGLWLDDVVYCPRHVICTSEDMLNPN
YEDLLIRKSNHNFLVQAGNVQLRVIGHSMQNCVLKLKVDTANPKTPKYKF
VRIQPGQTFSVLACYNGSPSGVYQCAMRPNFTIKGSFLNGSCGSVGFNID
YDCVSFCYMHHMELPTGVHAGTDLEGNFYGPFVDRQTAQAAGTDTTITVN
VLAWLYAAVINGDRWFLNRFTTTLNDFNLVAMKYNYEPLTQDHVDILGPL
SAQTGIAVLDMCASLKELLQNGMNGRTILGSALLEDEFTPFDVVRQCS

3D structure

PDB

6xmk 3C-like protease inhibitors block coronavirus replication in vitro and improve survival in MERS-CoV-infected mice.

Chain

Resolution

1.7 Å

3D
structure

[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]

Enzymatic activity

Enzyme Commision number

2.1.1.56: mRNA (guanine-N(7))-methyltransferase.
2.1.1.57: methyltransferase cap1.
2.7.7.48: RNA-directed RNA polymerase.
2.7.7.50: mRNA guanylyltransferase.
3.1.13.-
3.4.19.12: ubiquitinyl hydrolase 1.
3.4.22.-
3.4.22.69: SARS coronavirus main proteinase.
3.6.4.12: DNA helicase.
3.6.4.13: RNA helicase.
4.6.1.-

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	QYS	A	F140 N142 G143 C145 H163 H164 M165 E166 Q189 A191	F137 N139 G140 C142 H160 H161 M162 E163 Q186 A188	BindingDB: IC50=450nM

Gene Ontology

	Molecular Function
GO:0008233	peptidase activity

	Biological Process
GO:0019082	viral protein processing

View graph for
Molecular Function

View graph for
Biological Process

PDB	RCSB:6xmk, PDBe:6xmk, PDBj:6xmk
PDBsum	6xmk
PubMed	32747425
UniProt	P0DTD1\|R1AB_SARS2 Replicase polyprotein 1ab (Gene Name=rep)