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BioLiP

Structure of PDB 6whn Chain A

Receptor sequence
>6whnA (length=375) Species: 9606 (Homo sapiens) [Search protein sequence]
AAYSQGGGKKKVCYYYDGDIGNYYYGQGHPMKPHRIRMTHNLLLNYGLYR
KMEIYRPHKATAEEMTKYHSDEYIKFLRSIRPDNMSEYSKQMQRFNVGED
CPVFDGLFEFCQLSTGGSVAGAVKLNRQQTDMAVNWAGGLHHAKKSEASG
FCYVNDIVLAILELLKYHQRVLYIDIDIHHGDGVEEAFYTTDRVMTVSFH
KYGEYFPGTGDLRDIGAGKGKYYAVNFPMRDGIDDESYGQIFKPIISKVM
EMYQPSAVVLQCGADSLSGDRLGCFNLTVKGHAKCVEVVKTFNLPLLMLG
GGGYTIRNVARCWTYETAVALDCEIPNELPYNDYFEYFGPDFKLHISPSN
MTNQNTPEYMEKIKQRLFENLRMLP
3D structure
PDB6whn Anchor extension: a structure-guided approach to design cyclic peptides targeting enzyme active sites.
ChainA
Resolution1.54 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.5.1.-
3.5.1.98: histone deacetylase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A E103 H146 G154 F155 D181 H183 F210 L276 Y308 E99 H142 G150 F151 D177 H179 F206 L272 Y304
BS02 ZN A D181 H183 D269 D177 H179 D265
Gene Ontology
Molecular Function
GO:0004407 histone deacetylase activity

View graph for
Molecular Function
External links
PDB RCSB:6whn, PDBe:6whn, PDBj:6whn
PDBsum6whn
PubMed34099674
UniProtQ92769|HDAC2_HUMAN Histone deacetylase 2 (Gene Name=HDAC2)

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