BioLiP

Structure of PDB 6wh4 Chain A

Receptor sequence

>6wh4A (length=378) Species: 562,9606 [Search protein sequence]

LQEKNWSALLTAVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIAD
MLLGFLVMPVSMLTILYGYRWPLPSKLCAVWIYLDVLFSTASIMHLCAIS
LDRYVAIQNPIHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGLSKVFK
EGSCLLADDNFVLIGSFVSFFIPATIMVITYFLTIKSLQKEAADLEDNWE
TLNDNLKVIEKADNAAQVKDALTKMRAAALDAQKATPPKSPDSPEMKDFR
HGFDILVGQIDDALKLAKEAQAAAEQLKTTRNAYIQKYLTMQSISNEQKA
CKVLGIVFFLFVVMWCPFFITNIMAVICKESCNEDVIGALLNVFVWIGYA
SSAVNPLVYTLFNKTYRSAFSRYIQCQY

3D structure

PDB

6wh4 Structure of a Hallucinogen-Activated Gq-Coupled 5-HT 2A Serotonin Receptor

Chain

Resolution

3.4 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	89F	A	W151 D155 V156 S159 T160 I163 L229 V235 G238 W336 F340	W81 D85 V86 S89 T90 I93 L156 V162 G165 W315 F319
BS02	CLR	A	M97 Y394	M27 Y373

Gene Ontology

	Molecular Function
GO:0004930	G protein-coupled receptor activity
GO:0004993	G protein-coupled serotonin receptor activity
GO:0005506	iron ion binding
GO:0009055	electron transfer activity
GO:0020037	heme binding
GO:0046872	metal ion binding

	Biological Process
GO:0007186	G protein-coupled receptor signaling pathway
GO:0022900	electron transport chain

	Cellular Component
GO:0005886	plasma membrane
GO:0016020	membrane
GO:0042597	periplasmic space

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Molecular Function

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Cellular Component

PDB	RCSB:6wh4, PDBe:6wh4, PDBj:6wh4
PDBsum	6wh4
PubMed
UniProt	P0ABE7\|C562_ECOLX Soluble cytochrome b562 (Gene Name=cybC); P28223\|5HT2A_HUMAN 5-hydroxytryptamine receptor 2A (Gene Name=HTR2A)