Structure of PDB 6roz Chain A

Receptor sequence
>6rozA (length=102) Species: 9606 (Homo sapiens) [Search protein sequence]
SRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVT
HIKIQNTGDYYDLYGGEKFATLAELVQYYMEHHGQLKEKNGDVIELKYPL
NC
3D structure
PDB6roz Molecular mechanism of SHP2 activation by PD-1 stimulation.
ChainA
Resolution2.89 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.3.48: protein-tyrosine-phosphatase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A R32 S34 K35 S36 T42 H53 G67 G68 K89 E90 K91 R30 S32 K33 S34 T40 H51 G65 G66 K87 E88 K89
External links
PDB RCSB:6roz, PDBe:6roz, PDBj:6roz
PDBsum6roz
PubMed32064351
UniProtQ06124|PTN11_HUMAN Tyrosine-protein phosphatase non-receptor type 11 (Gene Name=PTPN11)

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