BioLiP

Structure of PDB 6qqx Chain A

Receptor sequence

>6qqxA (length=212) Species: 36809 (Mycobacteroides abscessus) [Search protein sequence]

SMKIDVVTIFPEYLQPVRQSLPGKAIDAGLVDVAVHDLRRWTHDVHKSVD
DSPYGGGPGMVMKPTVWGDALDEICTSETLLVVPTPAGYPFTQETAWQWS
TEDHLVIACGRYEGIDQRVADDAATRMRVREVSIGDYVLNGGEAAALVII
EAVLRLVPGVLSLLEGPSYTRPPSWRGMDVPPVLLSGDHAKIAAWRAEQS
RQRTIERRPDLL

3D structure

PDB

6qqx Fragment-based discovery of a new class of inhibitors targeting mycobacterial tRNA modification.

Chain

Resolution

2.69 Å

3D
structure

Catalytic site residues are labeled in the structure
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Enzymatic activity

Catalytic site (original residue number in PDB)	P85 E112 R154
Catalytic site (residue number reindexed from 1)	P86 E113 R155
Enzyme Commision number	2.1.1.228: tRNA (guanine(37)-N(1))-methyltransferase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	JCE	A	P83 T84 P85 G109 R110 Y111 E112 S132 I133 G134 Y136 L138 N139 G140 G141	P84 T85 P86 G110 R111 Y112 E113 S133 I134 G135 Y137 L139 N140 G141 G142

Gene Ontology

	Molecular Function
GO:0008168	methyltransferase activity
GO:0052906	tRNA (guanine(37)-N1)-methyltransferase activity

	Biological Process
GO:0002939	tRNA N1-guanine methylation
GO:0006400	tRNA modification
GO:0008033	tRNA processing
GO:0032259	methylation

	Cellular Component
GO:0005737	cytoplasm
GO:0005829	cytosol

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Molecular Function

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Biological Process

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Cellular Component

PDB	RCSB:6qqx, PDBe:6qqx, PDBj:6qqx
PDBsum	6qqx
PubMed	32602532
UniProt	B1MDI3