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BioLiP

Structure of PDB 6pxf Chain A

Receptor sequence
>6pxfA (length=215) Species: 9606 (Homo sapiens) [Search protein sequence]
APDSVDYRKKGYVTPVKNQGQCGSCWAFSSVGALEGQLKKKTGKLLNLAP
QNLVDCVSENDGCGGGYMTNAFQYVQKNRGIDSEDAYPYVGQEESCMYNP
TGKAAKCRGYREIPEGNEKALKRAVARVGPVSVAIDASLTSFQFYSKGVY
YDESCNSDNLNHAVLAVGYGIQKGNKHWIIKNSWGENWGNKGYILMARNK
NNACGIANLASFPKM
3D structure
PDB6pxf Structure of human Cathepsin K with an ectosteric inhibitor at 1.85 Angstrom resolution
ChainA
Resolution1.85 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) Q19 C25 H162 N182
Catalytic site (residue number reindexed from 1) Q19 C25 H162 N182
Enzyme Commision number 3.4.22.38: cathepsin K.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 J0V A N18 Y89 N187 N18 Y89 N187
BS02 J0V A Q76 K77 R79 Q76 K77 R79
BS03 J0V A R79 K103 K106 R79 K103 K106
BS04 J0V A R8 N190 K191 R8 N190 K191
Gene Ontology
Molecular Function
GO:0008234 cysteine-type peptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:6pxf, PDBe:6pxf, PDBj:6pxf
PDBsum6pxf
PubMed
UniProtP43235|CATK_HUMAN Cathepsin K (Gene Name=CTSK)

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