Structure of PDB 6m72 Chain A

Receptor sequence
>6m72A (length=291) Species: 246196 (Mycolicibacterium smegmatis MC2 155) [Search protein sequence]
HTVRAAGAVLWRDASTVEVAVIHRPRYDDWSLPKGKLDQGETEPVAAARE
IHEETGHTAVLGRRLGRVTYPIPQGTKRVWYWAAKSTGGDFSPNDEVDKL
VWLPVDAAMDQLQYPDDRKVLRRFVKRPVDTKTVLVVRHGTAGRRSRYKG
DDRKRPLDKRGRAQAEALVAQLMAFGATTLYAADRVRCHQTIEPLAQELD
QLIHNEPLLTEEAYAADHKAARKRLLEIAGRPGNPVICTQGKVIPGLIEW
WCERAKVRPETTGNRKGSTWVLSLSDGELVGADYLSPPDEK
3D structure
PDB6m72 Plasticity, ligand conformation and enzyme action of Mycobacterium smegmatis MutT1.
ChainA
Resolution1.6 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.1.58: 8-oxo-dGDP phosphatase.
3.6.1.61: diadenosine hexaphosphate hydrolase (ATP-forming).
3.6.1.69: 8-oxo-(d)GTP phosphatase.
Interaction with ligand
Site
#
Ligand Ligand
chain
Binding residues on receptor
(original residue number in PDB)
Binding residues on receptor
(residue number reindexed from 1)
Binding affinity
BS01 8GD A R55 Y58 K65 K67 Y101 K108 Y145 D148 R24 Y27 K34 K36 Y70 K77 Y114 D117
BS02 POP A R169 H170 R176 R186 R218 Q271 G272 K297 R138 H139 R145 R155 R187 Q240 G241 K266
BS03 MG A K65 E85 E127 K34 E54 E96
Gene Ontology
Molecular Function
GO:0008413 8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity
GO:0016787 hydrolase activity
GO:0044715 8-oxo-dGDP phosphatase activity
GO:0044716 8-oxo-GDP phosphatase activity
GO:0046872 metal ion binding
Biological Process
GO:0006260 DNA replication
GO:0006281 DNA repair

View graph for
Molecular Function

View graph for
Biological Process
External links
PDB RCSB:6m72, PDBe:6m72, PDBj:6m72
PDBsum6m72
PubMed33021500
UniProtA0QUZ2|MUTT1_MYCS2 8-oxo-(d)GTP phosphatase (Gene Name=mutT1)

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