BioLiP

Structure of PDB 6m72 Chain A

Receptor sequence

>6m72A (length=291) Species: 246196 (Mycolicibacterium smegmatis MC2 155) [Search protein sequence]

HTVRAAGAVLWRDASTVEVAVIHRPRYDDWSLPKGKLDQGETEPVAAARE
IHEETGHTAVLGRRLGRVTYPIPQGTKRVWYWAAKSTGGDFSPNDEVDKL
VWLPVDAAMDQLQYPDDRKVLRRFVKRPVDTKTVLVVRHGTAGRRSRYKG
DDRKRPLDKRGRAQAEALVAQLMAFGATTLYAADRVRCHQTIEPLAQELD
QLIHNEPLLTEEAYAADHKAARKRLLEIAGRPGNPVICTQGKVIPGLIEW
WCERAKVRPETTGNRKGSTWVLSLSDGELVGADYLSPPDEK

3D structure

PDB

6m72 Plasticity, ligand conformation and enzyme action of Mycobacterium smegmatis MutT1.

Chain

Resolution

1.6 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

3.6.1.58: 8-oxo-dGDP phosphatase.
3.6.1.61: diadenosine hexaphosphate hydrolase (ATP-forming).
3.6.1.69: 8-oxo-(d)GTP phosphatase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	8GD	A	R55 Y58 K65 K67 Y101 K108 Y145 D148	R24 Y27 K34 K36 Y70 K77 Y114 D117
BS02	POP	A	R169 H170 R176 R186 R218 Q271 G272 K297	R138 H139 R145 R155 R187 Q240 G241 K266
BS03	MG	A	K65 E85 E127	K34 E54 E96

Gene Ontology

	Molecular Function
GO:0008413	8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity
GO:0016787	hydrolase activity
GO:0044715	8-oxo-dGDP phosphatase activity
GO:0044716	8-oxo-GDP phosphatase activity
GO:0046872	metal ion binding

	Biological Process
GO:0006260	DNA replication
GO:0006281	DNA repair

View graph for
Molecular Function

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Biological Process

PDB	RCSB:6m72, PDBe:6m72, PDBj:6m72
PDBsum	6m72
PubMed	33021500
UniProt	A0QUZ2\|MUTT1_MYCS2 8-oxo-(d)GTP phosphatase (Gene Name=mutT1)