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BioLiP

Structure of PDB 6k38 Chain A

Receptor sequence

>6k38A (length=327) Species: 1148 (Synechocystis sp. PCC 6803) [Search protein sequence]

SLAPLRVGILGFGGLGQAAARLLAPKQEMKLVAVADRHGYLYDADGIDVD
NAVQAYTQQGSVGKAKKGQMSEQSIEDLIGEGEVDGYFLALPNLPNTFMA
DVTRQFIASGWQGVLVDALKRTSAVEQLITLREDLAQAGITYMTGCGATP
GLLTAAAAIASQSFQEIHQVKITFGVGIANWEAYRATIREDIAHMPGYNV
DKAQAMTDAEVAALLDQTNGILALEDMEAADDIMLELAGICHRDQVTVGG
VVDTRNPKKPLSTHVKITGRTFEGKISSHTFTLGDETSMAANVCGPAFGY
LKAGYGLHRQGLKGLFTAADVMPKFVR

3D structure

PDB

6k38 A suicide enzyme catalyzes multiple reactions for biotin biosynthesis in cyanobacteria.

Chain

Resolution

1.78 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

2.6.1.121: 8-amino-7-oxononanoate carboxylating dehydrogenase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	CWF	A	K124 F178 V180 D195 K263 T267 M293 N296	K120 F174 V176 D191 K259 T263 M289 N292

Gene Ontology

	Molecular Function
GO:0000166	nucleotide binding
GO:0008483	transaminase activity
GO:0016491	oxidoreductase activity
GO:0050661	NADP binding
GO:0051287	NAD binding

	Biological Process
GO:0006520	amino acid metabolic process
GO:0009102	biotin biosynthetic process

View graph for
Molecular Function

View graph for
Biological Process

External links

PDB	RCSB:6k38, PDBe:6k38, PDBj:6k38
PDBsum	6k38
PubMed	32042199
UniProt	Q55650\|BIOU_SYNY3 (S)-8-amino-7-oxononanoate synthase BioU (Gene Name=bioU)

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