Structure of PDB 6a94 Chain A

Receptor sequence
>6a94A (length=370) Species: 562,9606 [Search protein sequence]
THLQEKNWSALLTAVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAI
ADMLLGFLVMPVSMLTILYGYRWPLPSKLCAVWIYLDVLFSTAKIWHLCA
ISLDRYVAIQNPIHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQDD
SKVFKEGSCLLADDNFVLIGSFVSFFIPLTIMVITYFLTIKSLQKEAADL
EDNWETLNDNLKVIEKADNAAQVKDALTKMRAAALDAGSGSGDILVGQID
DALKLANEGKVKEAQAAAEQLKTTINAYIQKYGQSISNEQKACKVLGIVF
FLFVVMWCPFFITNIMAVICKESCNEDVIGALLNVFVWIGYLSSAVNPLV
YTLFNKTYRSAFSRYIQCQY
3D structure
PDB6a94 Structures of the 5-HT2Areceptor in complex with the antipsychotics risperidone and zotepine.
ChainA
Resolution2.9 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZOT A W151 D155 S159 L229 V235 G238 S242 W336 F339 F340 W83 D87 S91 L161 V167 G170 S174 W307 F310 F311 PDBbind-CN: -logKd/Ki=7.40,Ki=40nM
BS02 CLR A M114 I118 L122 Y153 W200 M46 I50 L54 Y85 W132
BS03 ZN A H182 H183 E264 E318 H114 H115 E196 E289
Gene Ontology
Molecular Function
GO:0004930 G protein-coupled receptor activity
GO:0004993 G protein-coupled serotonin receptor activity
GO:0005506 iron ion binding
GO:0009055 electron transfer activity
GO:0020037 heme binding
Biological Process
GO:0007186 G protein-coupled receptor signaling pathway
GO:0022900 electron transport chain
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane

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Cellular Component
External links
PDB RCSB:6a94, PDBe:6a94, PDBj:6a94
PDBsum6a94
PubMed30723326
UniProtP0ABE7|C562_ECOLX Soluble cytochrome b562 (Gene Name=cybC);
P28223|5HT2A_HUMAN 5-hydroxytryptamine receptor 2A (Gene Name=HTR2A)

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