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BioLiP

Structure of PDB 5zkb Chain A

Receptor sequence
>5zkbA (length=381) Species: 562,9606 [Search protein sequence]
PYKTFEVVFIVLVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNYFLFSLA
CADLIIGVFSMNLYTLYTVIGYWPLGPVVCDLWLALDYVVSNARVMNLLI
ISFDRYFCVTKPLTYPVKRTTKMAGMMIAAAWVLSFILWAPAILFWQFIV
GVRTVEDGECYIQFFSNAAVTFGTAIAAFYLPVIIMTVLYWHISRASKSR
IADLEDNWETLNDNLKVIEKADNAAQVKDALTKMRAAALDAQKATPPKLS
PEMKDFRHGFDILVGQIDDALKLANEGKVKEAQAAAEQLKTTRNAYIQKY
LPPPSREKKVTRTILAILLAFIITWAPYNVMVLINTFCAPCIPNTVWTIG
YWLCYINSTINPACYALCNATFKKTFKHLLM
3D structure
PDB5zkb Structural insights into the subtype-selective antagonist binding to the M2muscarinic receptor
ChainA
Resolution2.95 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 82F A W99 L100 D103 Y104 S107 N108 V111 A191 W400 Y403 N404 Y426 C429 Y430 W83 L84 D87 Y88 S91 N92 V95 A175 W325 Y328 N329 Y351 C354 Y355 PDBbind-CN: -logKd/Ki=8.70,Ki=2.0nM
Gene Ontology
Molecular Function
GO:0004930 G protein-coupled receptor activity
GO:0005506 iron ion binding
GO:0009055 electron transfer activity
GO:0016907 G protein-coupled acetylcholine receptor activity
GO:0020037 heme binding
GO:0046872 metal ion binding
Biological Process
GO:0007186 G protein-coupled receptor signaling pathway
GO:0022900 electron transport chain
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0042597 periplasmic space

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Cellular Component
External links
PDB RCSB:5zkb, PDBe:5zkb, PDBj:5zkb
PDBsum5zkb
PubMed30420692
UniProtP08172|ACM2_HUMAN Muscarinic acetylcholine receptor M2 (Gene Name=CHRM2);
P0ABE7|C562_ECOLX Soluble cytochrome b562 (Gene Name=cybC)

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