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BioLiP

Structure of PDB 5zk9 Chain A

Receptor sequence
>5zk9A (length=183) Species: 9606 (Homo sapiens) [Search protein sequence]
PEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQ
LSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFW
LETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIG
RVYKERLGLPPKIVIGYQSHADTATKTKNRFVV
3D structure
PDB5zk9 Structural insights reveal a recognition feature for tailoring hydrocarbon stapled-peptides against the eukaryotic translation initiation factor 4E protein.
ChainA
Resolution1.76 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A H37 P38 Q40 V69 W73 E132 L135 G139 E140 D147 H7 P8 Q10 V39 W43 E102 L105 G109 E110 D117
BS02 MGP A W56 M101 W102 E103 R157 K162 W26 M71 W72 E73 R127 K132 BindingDB: Ki=28nM
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003743 translation initiation factor activity
Biological Process
GO:0006413 translational initiation
Cellular Component
GO:0005737 cytoplasm

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Cellular Component
External links
PDB RCSB:5zk9, PDBe:5zk9, PDBj:5zk9
PDBsum5zk9
PubMed30881679
UniProtP06730|IF4E_HUMAN Eukaryotic translation initiation factor 4E (Gene Name=EIF4E)

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