BioLiP

Structure of PDB 5uxz Chain A

Receptor sequence

>5uxzA (length=290) Species: 1829 (Rhodococcus rhodochrous) [Search protein sequence]

IGTGFPFDPHYVEVLGERMHYVDVGPRDGTPVLFLHGNPTSSYVWRNIIP
HVAPTHRCIAPDLIGMGKSDKPDLGYFFDDHVRFMDAFIEALGLEEVVLV
IHDWGSALGFHWAKRNPERVKGIAFMEFIRPIPTWDEWPEFARETFQAFR
TTDVGRKLIIDQNVFIEGTLPMGVVRPLTEVEMDHYREPFLNPVDREPLW
RFPNELPIAGEPANIVALVEEYMDWLHQSPVPKLLFWGTPGVLIPPAEAA
RLAKSLPNCKAVDIGPGLNLLQEDNPDLIGSEIARWLSTL

3D structure

PDB

5uxz The Cation-pi Interaction Enables a Halo-Tag Fluorogenic Probe for Fast No-Wash Live Cell Imaging and Gel-Free Protein Quantification.

Chain

Resolution

1.92 Å

3D
structure

Catalytic site residues are labeled in the structure
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Enzymatic activity

Catalytic site (original residue number in PDB)	N41 D106 W107 E130 W141 T148 P206 G244 N272
Catalytic site (residue number reindexed from 1)	N38 D103 W104 E127 W138 T145 P203 G241 N269
Enzyme Commision number	3.8.1.5: haloalkane dehalogenase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	8PM	A	N41 D106 W141 A145 F149 T172 M175 G176 V245 N272	N38 D103 W138 A142 F146 T169 M172 G173 V242 N269

Gene Ontology

	Molecular Function
GO:0003824	catalytic activity
GO:0016787	hydrolase activity
GO:0018786	haloalkane dehalogenase activity

	Biological Process
GO:0009636	response to toxic substance

View graph for
Molecular Function

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Biological Process

PDB	RCSB:5uxz, PDBe:5uxz, PDBj:5uxz
PDBsum	5uxz
PubMed	28221782
UniProt	P0A3G2\|DHAA_RHORH Haloalkane dehalogenase (Gene Name=dhaA)