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Structure of PDB 5uvx Chain A

Receptor sequence

>5uvxA (length=108) Species: 9606 (Homo sapiens)

HMEQLKCCSGILKEMFAKKHAAYAWPFYKPVDVEALGLHDYCDIIKHPMD
MSTIKSKLEAREYRDAQEFGADVRLMFSNCYKYNPPDHEVVAMARKLQDV
FEMRFAKM

3D structure

• PDB: 5uvx BRD4 Bromodomain 2 with A-1359643
• Chain: A
• Resolution: 1.53 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	8NM	A	W374 P375 K378 P379 V380 L385 L387 N433 H437 V439 M442	W25 P26 K29 P30 V31 L36 L38 N84 H88 V90 M93	BindingDB: Ki=2.4nM,EC50=11nM

External links

• PDB: RCSB:5uvx, PDBe:5uvx, PDBj:5uvx
• PDBsum: 5uvx
• UniProt: O60885|BRD4_HUMAN Bromodomain-containing protein 4 (Gene Name=BRD4)

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