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BioLiP

Structure of PDB 4zcf Chain A

Receptor sequence
>4zcfA (length=616) Species: 562 (Escherichia coli) [Search protein sequence]
ANSKQLAVLKANFPQCFDKNGAFIQEKLLEIIRASEKESYSLNWLGKSYA
RLLANLPPKTLLAEDKTHNQQEENKNSQHLLIKGDNLEVLKHMVNAYAEK
VKMIYIDPPYNTGKDGFVYNDDRFTPEQLSELAGIDLDEAKRILEFTTKG
SSSHSAWLTFIYPRLYIARELMREDGTIFISIDHNEFSQLKLVCDEIFGE
QNHVGDLVWKNATDNNPSNIAVEHEYIIVYTKNKEQLISEWKSNISDVKN
LLVNIGEEFASKYTGNELQEKYTQWFREHRSELWPLDRYKYIDKDGIYTG
SQSVHNPGKEGYRYDIIHPKTKKPCKQPLMGYRFPLDTMDRLLSEEKIIF
GDDENKIIELKVYAKDYKQKLSSVIHLDGRVATNELKELFPMTQPFNAKT
IKLVEDLISFACDGEGIVLDFFAGSGTTAHTVFNLNNKNKTSYQFITVQL
DEPTKKSDAMKHGYNTIFDLTKERLIRASKKNRDQGFKVYQLMPDFRAKD
ESELTFFDDVVLTPEQYDTLLTTWCLYDGSLLTTPIEDVDLGGYKAHLCD
GRLYLIAPNFTSEALKALLQKVDSDKDFAPNKVVFYGSNFSAKQMELNEA
LKSYANSIELDLVVRN
3D structure
PDB4zcf Structural basis of asymmetric DNA methylation and ATP-triggered long-range diffusion by EcoP15I.
ChainA
Resolution2.6 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.1.1.72: site-specific DNA-methyltransferase (adenine-specific).
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna A R305 Q319 H322 P324 L346 K373 I374 R288 Q302 H305 P307 L329 K356 I357
BS02 dna A W301 R305 Y306 S320 N323 P324 Y329 R350 F351 P352 T355 W284 R288 Y289 S303 N306 P307 Y312 R333 F334 P335 T338
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0008168 methyltransferase activity
GO:0008170 N-methyltransferase activity
GO:0009007 site-specific DNA-methyltransferase (adenine-specific) activity
Biological Process
GO:0009307 DNA restriction-modification system
GO:0032259 methylation

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Molecular Function
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Biological Process
External links
PDB RCSB:4zcf, PDBe:4zcf, PDBj:4zcf
PDBsum4zcf
PubMed26067164
UniProtP12364|T3MO_ECOLX Type III restriction-modification enzyme EcoP15I Mod subunit (Gene Name=mod)

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