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BioLiP

Structure of PDB 4rh9 Chain A

Receptor sequence
>4rh9A (length=282) Species: 9606 (Homo sapiens) [Search protein sequence]
ADTLEGSMAQLKKGLESGTVLIQFEQLYRKKPGLAITFAKLPQNLDKNRY
KDVLPYDTTRVLLQGNEDYINASYVNMEIPAANLVNKYIATQGPLPHTCA
QFWQVVWDQKLSLIVMLTTLTERGRTKCHQYWPDPPDVMNHGGFHIQCQS
EDCTIAYVSREMLVTNTQTGEEHTVTHLQYVAWPAFGVPDDSSDFLEFVN
YVRSLRVDSEPVLVHSSAGIGRTGVLVTMETAMCLTERNLPIYPLDIVRK
MRDQRAGMVQTSSQYKFVCEAILRVYEEGLVQ
3D structure
PDB4rh9 Substrate specificity and plasticity of FERM-containing protein tyrosine phosphatases.
ChainA
Resolution1.598 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) A811 S842 R848 T849 Q886
Catalytic site (residue number reindexed from 1) A185 S216 R222 T223 Q260
Enzyme Commision number 3.1.3.48: protein-tyrosine-phosphatase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A D672 Y676 K677 D678 F812 S842 S843 A844 I846 G847 R848 Q886 D46 Y50 K51 D52 F186 S216 S217 A218 I220 G221 R222 Q260
Gene Ontology
Molecular Function
GO:0004725 protein tyrosine phosphatase activity
Biological Process
GO:0006470 protein dephosphorylation
GO:0016311 dephosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:4rh9, PDBe:4rh9, PDBj:4rh9
PDBsum4rh9
PubMed25728925
UniProtP26045|PTN3_HUMAN Tyrosine-protein phosphatase non-receptor type 3 (Gene Name=PTPN3)

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