BioLiP

Structure of PDB 4jia Chain A

Receptor sequence

>4jiaA (length=300) Species: 9606 (Homo sapiens) [Search protein sequence]

SGAFEDRDPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVK
KLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYL
PYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNI
LVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFS
VASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELL
KNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALRVDQIRDNMAG

3D structure

PDB

4jia 2-Amino-[1,2,4]triazolo[1,5-a]pyridines as JAK2 inhibitors.

Chain

Resolution

1.85 Å

3D
structure

Catalytic site residues are labeled in the structure
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Enzymatic activity

Catalytic site (original residue number in PDB)	D976 A978 R980 N981 D994 S1016
Catalytic site (residue number reindexed from 1)	D144 A146 R148 N149 D162 S184
Enzyme Commision number	2.7.10.2: non-specific protein-tyrosine kinase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	1K3	A	V863 A880 M929 Y931 L932 G935 L983	V31 A48 M97 Y99 L100 G103 L151	MOAD: Ki=0.0006uM PDBbind-CN: -logKd/Ki=9.22,Ki=0.6nM BindingDB: Ki=0.600000nM,IC50=22nM

Gene Ontology

	Molecular Function
GO:0004672	protein kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005524	ATP binding

	Biological Process
GO:0006468	protein phosphorylation

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Molecular Function

View graph for
Biological Process

PDB	RCSB:4jia, PDBe:4jia, PDBj:4jia
PDBsum	4jia
PubMed	23870430
UniProt	O60674\|JAK2_HUMAN Tyrosine-protein kinase JAK2 (Gene Name=JAK2)