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Structure of PDB 4h1w Chain A

Receptor sequence

>4h1wA (length=985) Species: 9986 (Oryctolagus cuniculus)

MEAAHSKSTEECLAYFGVSETTGLTPDQVKRHLEKYGHNELPAEEGKSLW
ELVIEQFEDLLVRILLLAACISFVLAWFETAFVEPFVILLILIANAIVGV
WQERNAENAIEALKEYEPEMGKVYRADRKSVQRIKARDIVPGDIVEVAVG
DKVPADIRILSIKSTTLRVDQSILTGESVSVIKHTEPVPDPRAVNQDKKN
MLFSGTNIAAGKALGIVATTGVSTEIGKIRDQMAATEQDKTPLQQKLDEF
GEQLSKVISLICVAVWLINIGHFNDPVHGGSWIRGAIYYFKIAVALAVAA
IPEGLPAVITTCLALGTRRMAKKNAIVRSLPSVETLGCTSVICSDKTGTL
TTNQMSVCKMFIIDKVDGDFCSLNEFSITGSTYAPEGEVLKNDKPIRSGQ
FDGLVELATICALCNDSSLDFNETKGVYEKVGEATETALTTLVEKMNVFN
TEVRNLSKVERANACNSVIRQLMKKEFTLEFSRDRKSMSVYCSPAKSSRA
AVGNKMFVKGAPEGVIDRCNYVRVGTTRVPMTGPVKEKILSVIKEWGTGR
DTLRCLALATRDTPPKREEMVLDDSSRFMEYETDLTFVGVVGMLDPPRKE
VMGSIQLCRDAGIRVIMITGDNKGTAIAICRRIGIFGENEEVADRAYTGR
EFDDLPLAEQREACRRACCFARVEPSHKSKIVEYLQSYDEITAMTGDGVN
DAPALKKAEIGIAMGSGTAVAKTASEMVLADDNFSTIVAAVEEGRAIYNN
MKQFIRYLISSNVGEVVCIFLTAALGLPEALIPVQLLWVNLVTDGLPATA
LGFNPPDLDIMDRPPRSPKEPLISGWLFFRYMAIGGYVGAATVGAAAWWF
MYAEDGPGVTYHQLTHFMQCTEDHPHFDCEIFEAPEPMTMALSVLVTIEM
CNALNSLSENQSLMRMPPWVNIWLLGSICLSMSLHFLILYVDPLPMIFKL
KALDLTQWLMVLKISLPVIGLDEILKFIARNYLEG

3D structure

• PDB: 4h1w The sarcolipin-bound calcium pump stabilizes calcium sites exposed to the cytoplasm.
• Chain: A
• Resolution: 3.1 Å

Enzymatic activity

• Catalytic site (original residue number in PDB): D351 D703 D707
• Catalytic site (residue number reindexed from 1): D345 D697 D701
• Enzyme Commision number: 7.2.2.10: P-type Ca(2+) transporter.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	MG	A	V304 A305 E309	V298 A299 E303
BS02	MG	A	N796 D800	N790 D794
BS03	ACP	A	K352 T353 R560 T625 G626	K346 T347 R554 T619 G620

Gene Ontology

Molecular Function

• GO:0000166 nucleotide binding
• GO:0005215 transporter activity
• GO:0005388 P-type calcium transporter activity
• GO:0005509 calcium ion binding
• GO:0005524 ATP binding
• GO:0016887 ATP hydrolysis activity
• GO:0046872 metal ion binding

Biological Process

• GO:0006816 calcium ion transport
• GO:0006874 intracellular calcium ion homeostasis
• GO:0031448 positive regulation of fast-twitch skeletal muscle fiber contraction
• GO:0070588 calcium ion transmembrane transport
• GO:0106134 positive regulation of cardiac muscle cell contraction
• GO:1901896 positive regulation of ATPase-coupled calcium transmembrane transporter activity
• GO:1902082 positive regulation of calcium ion import into sarcoplasmic reticulum
• GO:1990036 calcium ion import into sarcoplasmic reticulum

Cellular Component

• GO:0016020 membrane
• GO:0016529 sarcoplasmic reticulum
• GO:0033017 sarcoplasmic reticulum membrane

External links

• PDB: RCSB:4h1w, PDBe:4h1w, PDBj:4h1w
• PDBsum: 4h1w
• PubMed: 23455424
• UniProt: P04191|AT2A1_RABIT Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 (Gene Name=ATP2A1)

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