BioLiP

Structure of PDB 4f0f Chain A

Receptor sequence

>4f0fA (length=276) Species: 44689 (Dictyostelium discoideum) [Search protein sequence]

RLPTLADNEIEYEKQIGKGGFGLVHKGRLVKDKSVVAIKSLILGDSEGET
EMIEKFQEFQREVFIMSNLNHPNIVKLYGLMHNPPRMVMEFVPCGDLYHR
LLDKAHPIKWSVKLRLMLDIALGIEYMQNQNPPIVHRDLRSPNIFLQSLD
ENAPVCAKVADFGLSQQSVHSVSGLLGNFQWMAPETIGAEEESYTEKADT
YSFAMILYTILTGEGPFDEYSYGKIKFINMIREEGLRPTIPEDCPPRLRN
VIELCWSGDPKKRPHFSYIVKELSEL

3D structure

PDB

4f0f Roco kinase structures give insights into the mechanism of Parkinson disease-related leucine-rich-repeat kinase 2 mutations.

Chain

Resolution

1.8 Å

3D
structure

Catalytic site residues are labeled in the structure
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Enzymatic activity

Catalytic site (original residue number in PDB)	D1154 R1156 P1158 N1159 D1177 N1194
Catalytic site (residue number reindexed from 1)	D138 R140 P142 N143 D161 N178
Enzyme Commision number	2.7.11.1: non-specific serine/threonine protein kinase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	ACP	A	K1034 V1040 A1053 F1107 V1108 R1156 F1161 D1177	K18 V24 A37 F91 V92 R140 F145 D161

Gene Ontology

	Molecular Function
GO:0004672	protein kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005524	ATP binding

	Biological Process
GO:0006468	protein phosphorylation

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Molecular Function

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Biological Process

PDB	RCSB:4f0f, PDBe:4f0f, PDBj:4f0f
PDBsum	4f0f
PubMed	22689969
UniProt	Q6XHB2\|ROCO4_DICDI Probable serine/threonine-protein kinase roco4 (Gene Name=roco4)