Structure of PDB 4dd0 Chain A

Receptor sequence

>4dd0A (length=129) Species: 9031 (Gallus gallus)

KVFGRCELAAAMKRHGLDNYRGYSLGNWVCAAKFESNFNTQATNRNTDGS
TDYGILQINSRWWCNDGRTPGSRNLCNIPCSALLSSDITASVNCAKKIVS
DGNGMNAWVAWRNRCKGTDVQAWIRGCRL

3D structure

• PDB: 4dd0 Structural studies of the effect that dimethyl sulfoxide (DMSO) has on cisplatin and carboplatin binding to histidine in a protein.
• Chain: A
• Resolution: 1.7 Å

Enzymatic activity

• Catalytic site (original residue number in PDB): E35 N46 D48 S50 D52 N59
• Catalytic site (residue number reindexed from 1): E35 N46 D48 S50 D52 N59
• Enzyme Commision number: 3.2.1.17: lysozyme.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	GOL	A	S36 A42 N44	S36 A42 N44
BS02	GOL	A	W62 L75 D101	W62 L75 D101
BS03	GOL	A	Q57 N59 A107 W108	Q57 N59 A107 W108
BS04	GOL	A	G4 C6 E7	G4 C6 E7
BS05	GOL	A	R14 H15 D87 I88 T89	R14 H15 D87 I88 T89
BS06	GOL	A	K33 F38	K33 F38
BS07	GOL	A	A82 D87	A82 D87
BS08	GOL	A	D48 R61 T69 P70	D48 R61 T69 P70

Gene Ontology

Molecular Function

• GO:0003796 lysozyme activity
• GO:0005515 protein binding
• GO:0016231 beta-N-acetylglucosaminidase activity
• GO:0016798 hydrolase activity, acting on glycosyl bonds
• GO:0042802 identical protein binding

Biological Process

• GO:0016998 cell wall macromolecule catabolic process
• GO:0031640 killing of cells of another organism
• GO:0042742 defense response to bacterium
• GO:0050829 defense response to Gram-negative bacterium
• GO:0050830 defense response to Gram-positive bacterium

Cellular Component

• GO:0005576 extracellular region
• GO:0005615 extracellular space
• GO:0005737 cytoplasm
• GO:0005783 endoplasmic reticulum

External links

• PDB: RCSB:4dd0, PDBe:4dd0, PDBj:4dd0
• PDBsum: 4dd0
• PubMed: 22525758
• UniProt: P00698|LYSC_CHICK Lysozyme C (Gene Name=LYZ)