BioLiP

Structure of PDB 4ctj Chain A

Receptor sequence

>4ctjA (length=256) Species: 11069 (dengue virus type 3) [Search protein sequence]

ETLGEKWKKKLNQLSRKEFDLYKKSGITEVDRTEAKEGLKRGETTHHAVS
RGSAKLQWFVERNMVIPEGRVIDLGCGRGGWSYYCAGLKKVTEVRGYTKG
GPGHEEPVPMSTYGWNIVKLMSGKDVFYLPPEKCDTLLCDIGESSPSPTV
EESRTIRVLKMVEPWLKNNQFCIKVLNPYMPTVIEHLERLQRKHGGMLVR
NPLSRNSTHEMYWISNGTGNIVSSVNMVSRLLLNRFTMTHRRPTIEKDVD
LGAGTR

3D structure

PDB

4ctj Assessment of Dengue Virus Helicase and Methyltransferase as Targets for Fragment-Based Drug Discovery.

Chain

Resolution

1.47 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

3.4.21.91: flavivirin.
3.6.1.15: nucleoside-triphosphate phosphatase.
3.6.4.13: RNA helicase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	SAM	A	S56 G58 G81 G86 W87 T104 K105 H110 K130 D131 V132 F133 D146	S50 G52 G75 G80 W81 T98 K99 H104 K124 D125 V126 F127 D140
BS02	3A9	A	L237 R241 M244 R247	L231 R235 M238 R241	PDBbind-CN: -logKd/Ki=2.51,IC50=3.12mM

Gene Ontology

	Molecular Function
GO:0004482	mRNA 5'-cap (guanine-N7-)-methyltransferase activity
GO:0004483	mRNA (nucleoside-2'-O-)-methyltransferase activity
GO:0008168	methyltransferase activity

	Biological Process
GO:0032259	methylation

View graph for
Molecular Function

View graph for
Biological Process

PDB	RCSB:4ctj, PDBe:4ctj, PDBj:4ctj
PDBsum	4ctj
PubMed	24704437
UniProt	A9LIE0